7b81

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Current revision (07:47, 1 May 2024) (edit) (undo)
 
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<StructureSection load='7b81' size='340' side='right'caption='[[7b81]], [[Resolution|resolution]] 2.09&Aring;' scene=''>
<StructureSection load='7b81' size='340' side='right'caption='[[7b81]], [[Resolution|resolution]] 2.09&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[7b81]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Azovd Azovd]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7B81 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7B81 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[7b81]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Azotobacter_vinelandii_DJ Azotobacter vinelandii DJ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7B81 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7B81 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.092&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Avin_09160 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=322710 AZOVD])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7b81 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7b81 OCA], [https://pdbe.org/7b81 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7b81 RCSB], [https://www.ebi.ac.uk/pdbsum/7b81 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7b81 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7b81 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7b81 OCA], [https://pdbe.org/7b81 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7b81 RCSB], [https://www.ebi.ac.uk/pdbsum/7b81 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7b81 ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/C1DMX5_AZOVD C1DMX5_AZOVD]
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Several microorganisms can utilize L-rhamnose as a carbon and energy source through the non-phosphorylative metabolic pathway, in which L-rhamnose 1-dehydrogenase (RhaDH) catalyzes the NAD(P)(+) -dependent oxidization of L-rhamnose to L-rhamnono-1,4-lactone. We herein investigated the crystal structures of RhaDH from Azotobacter vinelandii in ligand-free, NAD(+) -bound, NADP(+) -bound, and L-rhamnose- and NAD(+) -bound forms at 1.9, 2.1, 2.4, and 1.6 A resolution, respectively. The significant interactions with the 2'-phosphate group of NADP(+) , but not the 2'-hydroxyl group of NAD(+) , were consistent with a preference for NADP(+) over NAD(+) . The C5-OH and C6-methyl groups of L-rhamnose were recognized by specific residues of RhaDH through hydrogen bonds and hydrophobic contact, respectively, which contribute to the different substrate specificities from other aldose 1-dehydrogenases in the short-chain dehydrogenase/reductase superfamily.
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Crystal structure of L-rhamnose 1-dehydrogenase involved in the non-phosphorylative pathway of L-rhamnose metabolism in bacteria.,Yoshiwara K, Watanabe S, Watanabe Y FEBS Lett. 2021 Jan 22. doi: 10.1002/1873-3468.14046. PMID:33482017<ref>PMID:33482017</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 7b81" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Azovd]]
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[[Category: Azotobacter vinelandii DJ]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Watanabe, S]]
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[[Category: Watanabe S]]
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[[Category: Watanabe, Y]]
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[[Category: Watanabe Y]]
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[[Category: Yoshiwara, K]]
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[[Category: Yoshiwara K]]
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[[Category: L-rhanose metabolism]]
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[[Category: Nadp-dependent dehydrogenase]]
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[[Category: Oxidoreductase]]
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[[Category: Sdr protein family]]
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Current revision

Crystal structure of Azotobacter vinelandii L-rhamnose 1-dehydrogenase (NAD bound-form)

PDB ID 7b81

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