7bbi

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<StructureSection load='7bbi' size='340' side='right'caption='[[7bbi]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
<StructureSection load='7bbi' size='340' side='right'caption='[[7bbi]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[7bbi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Ccm_7076 Ccm 7076]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7BBI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7BBI FirstGlance]. <br>
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<table><tr><td colspan='2'>[[7bbi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Photorhabdus_laumondii Photorhabdus laumondii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7BBI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7BBI FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CKY10_20885 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2218628 CCM 7076])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Hybrid , Neutron Diffraction , X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7bbi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7bbi OCA], [https://pdbe.org/7bbi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7bbi RCSB], [https://www.ebi.ac.uk/pdbsum/7bbi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7bbi ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7bbi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7bbi OCA], [https://pdbe.org/7bbi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7bbi RCSB], [https://www.ebi.ac.uk/pdbsum/7bbi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7bbi ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/Q7N8J0_PHOLL Q7N8J0_PHOLL]
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Carbohydrate-binding proteins from pathogenic bacteria and fungi have been shown to be implicated in various pathological processes, where they interact with glycans present on the surface of the host cells. These interactions are part of the initial processes of infection of the host and are very important to study at the atomic level. Here, we report the room temperature neutron structures of PLL lectin from Photorhabdus laumondii in its apo form and in complex with deuterated L-fucose, which is, to our knowledge, the first neutron structure of a carbohydrate-binding protein in complex with a fully deuterated carbohydrate ligand. A detailed structural analysis of the lectin-carbohydrate interactions provides information on the hydrogen bond network, the role of water molecules, and the extent of the CH-pi stacking interactions between fucose and the aromatic amino acids in the binding site.
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Visualization of hydrogen atoms in a perdeuterated lectin-fucose complex reveals key details of protein-carbohydrate interactions.,Gajdos L, Blakeley MP, Kumar A, Wimmerova M, Haertlein M, Forsyth VT, Imberty A, Devos JM Structure. 2021 Mar 24. pii: S0969-2126(21)00076-9. doi:, 10.1016/j.str.2021.03.003. PMID:33765407<ref>PMID:33765407</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 7bbi" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Ccm 7076]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Blakeley, M P]]
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[[Category: Photorhabdus laumondii]]
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[[Category: Devos, J M]]
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[[Category: Blakeley MP]]
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[[Category: Forsyth, V T]]
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[[Category: Devos JM]]
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[[Category: Gajdos, L]]
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[[Category: Forsyth VT]]
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[[Category: Haertlein, M]]
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[[Category: Gajdos L]]
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[[Category: Imberty, A]]
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[[Category: Haertlein M]]
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[[Category: Kumar, A]]
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[[Category: Imberty A]]
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[[Category: Wimmerova, M]]
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[[Category: Kumar A]]
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[[Category: Propeller]]
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[[Category: Wimmerova M]]
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[[Category: Sugar binding protein]]
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Revision as of 07:48, 1 May 2024

Joint X-ray/neutron room temperature structure of H/D-exchanged PLL lectin

PDB ID 7bbi

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