7oh2

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Current revision (07:51, 1 May 2024) (edit) (undo)
 
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<StructureSection load='7oh2' size='340' side='right'caption='[[7oh2]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
<StructureSection load='7oh2' size='340' side='right'caption='[[7oh2]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[7oh2]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7OH2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7OH2 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[7oh2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rhizobium_oryzae Rhizobium oryzae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7OH2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7OH2 FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7oh2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7oh2 OCA], [https://pdbe.org/7oh2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7oh2 RCSB], [https://www.ebi.ac.uk/pdbsum/7oh2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7oh2 ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7oh2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7oh2 OCA], [https://pdbe.org/7oh2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7oh2 RCSB], [https://www.ebi.ac.uk/pdbsum/7oh2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7oh2 ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/A0A1X7D696_9HYPH A0A1X7D696_9HYPH]
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Catabolism of sulfoquinovose (SQ; 6-deoxy-6-sulfoglucose), the ubiquitous sulfosugar produced by photosynthetic organisms, is an important component of the biogeochemical carbon and sulfur cycles. Here, we describe a pathway for SQ degradation that involves oxidative desulfurization to release sulfite and enable utilization of the entire carbon skeleton of the sugar to support the growth of the plant pathogen Agrobacterium tumefaciens SQ or its glycoside sulfoquinovosyl glycerol are imported into the cell by an ATP-binding cassette transporter system with an associated SQ binding protein. A sulfoquinovosidase hydrolyzes the SQ glycoside and the liberated SQ is acted on by a flavin mononucleotide-dependent sulfoquinovose monooxygenase, in concert with an NADH-dependent flavin reductase, to release sulfite and 6-oxo-glucose. An NAD(P)H-dependent oxidoreductase reduces the 6-oxo-glucose to glucose, enabling entry into primary metabolic pathways. Structural and biochemical studies provide detailed insights into the recognition of key metabolites by proteins in this pathway. Bioinformatic analyses reveal that the sulfoquinovose monooxygenase pathway is distributed across Alpha- and Betaproteobacteria and is especially prevalent within the Rhizobiales order. This strategy for SQ catabolism is distinct from previously described pathways because it enables the complete utilization of all carbons within SQ by a single organism with concomitant production of inorganic sulfite.
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Oxidative desulfurization pathway for complete catabolism of sulfoquinovose by bacteria.,Sharma M, Lingford JP, Petricevic M, Snow AJD, Zhang Y, Jarva MA, Mui JW, Scott NE, Saunders EC, Mao R, Epa R, da Silva BM, Pires DEV, Ascher DB, McConville MJ, Davies GJ, Williams SJ, Goddard-Borger ED Proc Natl Acad Sci U S A. 2022 Jan 25;119(4). pii: 2116022119. doi:, 10.1073/pnas.2116022119. PMID:35074914<ref>PMID:35074914</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 7oh2" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Davies, G J]]
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[[Category: Rhizobium oryzae]]
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[[Category: Sharma, M]]
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[[Category: Davies GJ]]
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[[Category: Flavin-dependent]]
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[[Category: Sharma M]]
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[[Category: Monooxygenase]]
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[[Category: Native]]
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[[Category: Oxidoreductase]]
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Current revision

Crystal structure of FMNH2-dependent monooxygenase for oxidative desulfurization of sulfoquinovose

PDB ID 7oh2

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