7omz
From Proteopedia
(Difference between revisions)
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| - | ==== | + | ==Thermus sp. 2.9 DarT in complex with ADP-ribosylated ssDNA and nicotinamide== |
| - | <StructureSection load='7omz' size='340' side='right'caption='[[7omz]]' scene=''> | + | <StructureSection load='7omz' size='340' side='right'caption='[[7omz]], [[Resolution|resolution]] 1.66Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7omz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_sp._2.9 Thermus sp. 2.9]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7OMZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7OMZ FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7omz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7omz OCA], [https://pdbe.org/7omz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7omz RCSB], [https://www.ebi.ac.uk/pdbsum/7omz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7omz ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.66Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AR6:[(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL+[HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL]+HYDROGEN+PHOSPHATE'>AR6</scene>, <scene name='pdbligand=NCA:NICOTINAMIDE'>NCA</scene>, <scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7omz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7omz OCA], [https://pdbe.org/7omz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7omz RCSB], [https://www.ebi.ac.uk/pdbsum/7omz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7omz ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/DART_THES0 DART_THES0] Toxic component of a hybrid type II/IV toxin-antitoxin (TA) system. ADP-ribosylates ssDNA on the second thymidine of the consensus sequence 5'-TNTC-3'; the protein does not auto-modify. Arg-51 is highly flexible, allowing it to assume multiple positions in the crystal structures (PubMed:34408320). Its toxic effect is neutralized by cognate antitoxin DarG (By similarity).[UniProtKB:O53604]<ref>PMID:34408320</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: | + | [[Category: Thermus sp. 2 9]] |
| + | [[Category: Ariza A]] | ||
| + | [[Category: Schuller M]] | ||
Current revision
Thermus sp. 2.9 DarT in complex with ADP-ribosylated ssDNA and nicotinamide
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