1rwu
From Proteopedia
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==Solution structure of conserved protein YbeD from E. coli== | ==Solution structure of conserved protein YbeD from E. coli== | ||
| - | <StructureSection load='1rwu' size='340' side='right'caption='[[1rwu | + | <StructureSection load='1rwu' size='340' side='right'caption='[[1rwu]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[1rwu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[1rwu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RWU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1RWU FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1rwu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rwu OCA], [https://pdbe.org/1rwu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1rwu RCSB], [https://www.ebi.ac.uk/pdbsum/1rwu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1rwu ProSAT], [https://www.topsan.org/Proteins/NESGC/1rwu TOPSAN]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1rwu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rwu OCA], [https://pdbe.org/1rwu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1rwu RCSB], [https://www.ebi.ac.uk/pdbsum/1rwu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1rwu ProSAT], [https://www.topsan.org/Proteins/NESGC/1rwu TOPSAN]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/YBED_ECOLI YBED_ECOLI] | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1rwu ConSurf]. | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1rwu ConSurf]. | ||
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
| - | <div style="background-color:#fffaf0;"> | ||
| - | == Publication Abstract from PubMed == | ||
| - | Lipoic acid is an essential prosthetic group in several metabolic pathways. The biosynthetic pathway of protein lipoylation in Escherichia coli involves gene products of the lip operon. YbeD is a conserved bacterial protein located in the dacA-lipB intergenic region. Here, we report the nuclear magnetic resonance structure of YbeD from E. coli. The structure includes a beta alpha beta beta alpha beta fold with two alpha-helices on one side of a four-strand antiparallel beta-sheet. The beta 2-beta 3 loop shows the highest sequence conservation and is likely functionally important. The beta-sheet surface contains a patch of conserved hydrophobic residues, suggesting a role in protein-protein interactions. YbeD shows striking structural homology to the regulatory domain from d-3-phosphoglycerate dehydrogenase, hinting at a role in the allosteric regulation of lipoic acid biosynthesis or the glycine cleavage system. | ||
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| - | Structural similarity of YbeD protein from Escherichia coli to allosteric regulatory domains.,Kozlov G, Elias D, Semesi A, Yee A, Cygler M, Gehring K J Bacteriol. 2004 Dec;186(23):8083-8. PMID:15547281<ref>PMID:15547281</ref> | ||
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| - | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| - | </div> | ||
| - | <div class="pdbe-citations 1rwu" style="background-color:#fffaf0;"></div> | ||
| - | == References == | ||
| - | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Escherichia coli]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Arrowsmith | + | [[Category: Arrowsmith CH]] |
| - | [[Category: Gehring | + | [[Category: Gehring K]] |
| - | [[Category: Kozlov | + | [[Category: Kozlov G]] |
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Revision as of 08:27, 1 May 2024
Solution structure of conserved protein YbeD from E. coli
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