1ssf

<StructureSection load='1ssf' size='340' side='right'caption='[[1ssf]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>

<table><tr><td colspan='2'>[[1ssf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SSF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SSF FirstGlance]. <br>

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ssf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ssf OCA], [https://pdbe.org/1ssf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ssf RCSB], [https://www.ebi.ac.uk/pdbsum/1ssf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ssf ProSAT]</span></td></tr>

[[https://www.uniprot.org/uniprot/TP53B_MOUSE TP53B_MOUSE]] Plays a key role in the response to DNA damage. May have a role in checkpoint signaling during mitosis. Enhances TP53-mediated transcriptional activation (By similarity).<ref>PMID:11801725</ref>

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== Publication Abstract from PubMed ==

53BP1 is a key transducer of the DNA damage checkpoint signal, which is required for phosphorylation of a subset of ATM substrates and p53 accumulation. After cell irradiation, the 53BP1 N-terminal region is phosphorylated. Its two C-terminal BRCT motifs interact with p53. Its central region is required and sufficient for 53BP1 foci formation at DNA strand breaks and for 53BP1 binding to the kinetochore. It contains an RG-rich segment and interacts with DNA in vitro. Here we show that the major globular domain of the 53BP1 central region adopts a new structural motif composed of two tightly packed Tudor domains and a C-terminal alpha helix. A unique surface essentially located on the first Tudor domain is involved in the binding to 53BP1 RG-rich sequence and to DNA, suggesting that the Tudor tandem can act as an adaptor mediating intramolecular as well as intermolecular protein-protein interactions and protein-nucleic acid associations.

The Tudor tandem of 53BP1: a new structural motif involved in DNA and RG-rich peptide binding.,Charier G, Couprie J, Alpha-Bazin B, Meyer V, Quemeneur E, Guerois R, Callebaut I, Gilquin B, Zinn-Justin S Structure. 2004 Sep;12(9):1551-62. PMID:15341721<ref>PMID:15341721</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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<div class="pdbe-citations 1ssf" style="background-color:#fffaf0;"></div>

[[Category: Lk3 transgenic mice]]

[[Category: Alpha-Bazin, B]]

[[Category: Callebaut, I]]

[[Category: Charier, G]]

[[Category: Couprie, J]]

[[Category: Gilquin, B]]

[[Category: Guerois, R]]

[[Category: Meyer, V]]

[[Category: Quemeneur, E]]

[[Category: Zinn-Justin, S]]

[[Category: Tudor domain]]