1rwl

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[[Image:1rwl.jpg|left|200px]]
[[Image:1rwl.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1rwl |SIZE=350|CAPTION= <scene name='initialview01'>1rwl</scene>, resolution 1.9&Aring;
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The line below this paragraph, containing "STRUCTURE_1rwl", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= PKND, RV0931C, MT0958, MTCY08C9.08 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 Mycobacterium tuberculosis])
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-->
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|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3391 COG3391], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=pfam01436 NHL]</span>
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{{STRUCTURE_1rwl| PDB=1rwl | SCENE= }}
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|RELATEDENTRY=[[1rwi|1RWI]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rwl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rwl OCA], [http://www.ebi.ac.uk/pdbsum/1rwl PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1rwl RCSB]</span>
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}}
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'''Extracellular domain of Mycobacterium tuberculosis PknD'''
'''Extracellular domain of Mycobacterium tuberculosis PknD'''
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[[Category: TBSGC, TB Structural Genomics Consortium.]]
[[Category: TBSGC, TB Structural Genomics Consortium.]]
[[Category: Young, T A.]]
[[Category: Young, T A.]]
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[[Category: beta propeller]]
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[[Category: Beta propeller]]
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[[Category: protein structure initiative]]
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[[Category: Protein structure initiative]]
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[[Category: psi]]
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[[Category: Psi]]
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[[Category: structural genomic]]
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[[Category: Structural genomic]]
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[[Category: tb structural genomics consortium]]
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[[Category: Tb structural genomics consortium]]
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[[Category: tbsgc]]
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[[Category: Tbsgc]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:59:35 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:34:03 2008''
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Revision as of 04:59, 3 May 2008

Image:1rwl.jpg

Template:STRUCTURE 1rwl

Extracellular domain of Mycobacterium tuberculosis PknD


Overview

Diverse pathogenic bacteria produce transmembrane receptor Ser/Thr protein kinases (STPKs), but little is known about the signals mediated by these "eukaryotic-like" proteins. To explore the basis for signaling in the bacterial STPK receptor family, we determined the structure of the sensor domain of Mycobacterium tuberculosis PknD. In two crystal forms, the PknD sensor domain forms a rigid, six-bladed beta-propeller with a flexible tether to the transmembrane domain. The PknD sensor domain is the most symmetric beta-propeller structure described. All residues that vary most among the blade subdomains cluster in the large "cup" motif, analogous to the ligand-binding surface in many beta-propeller proteins. These results suggest that PknD binds a multivalent ligand that signals by changing the quaternary structure of the intracellular kinase domain.

About this Structure

1RWL is a Single protein structure of sequence from Mycobacterium tuberculosis. Full crystallographic information is available from OCA.

Reference

Sensor domain of the Mycobacterium tuberculosis receptor Ser/Thr protein kinase, PknD, forms a highly symmetric beta propeller., Good MC, Greenstein AE, Young TA, Ng HL, Alber T, J Mol Biol. 2004 May 28;339(2):459-69. PMID:15136047 Page seeded by OCA on Sat May 3 07:59:35 2008

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