This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
1tem
From Proteopedia
(Difference between revisions)
| Line 3: | Line 3: | ||
<StructureSection load='1tem' size='340' side='right'caption='[[1tem]], [[Resolution|resolution]] 1.95Å' scene=''> | <StructureSection load='1tem' size='340' side='right'caption='[[1tem]], [[Resolution|resolution]] 1.95Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[1tem]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[1tem]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. The July 2015 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''New Delhi Metallo-b-Lactamase'' by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2015_7 10.2210/rcsb_pdb/mom_2015_7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TEM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TEM FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ALP:2-(1-CARBOXY-2-HYDROXY-ETHYL)-5,5-DIMETHYL-THIAZOLIDINE-4-CARBOXYLIC+ACID'>ALP</scene></td></tr> |
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tem FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tem OCA], [https://pdbe.org/1tem PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tem RCSB], [https://www.ebi.ac.uk/pdbsum/1tem PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tem ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tem FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tem OCA], [https://pdbe.org/1tem PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tem RCSB], [https://www.ebi.ac.uk/pdbsum/1tem PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tem ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/BLAT_ECOLX BLAT_ECOLX] TEM-type are the most prevalent beta-lactamases in enterobacteria; they hydrolyze the beta-lactam bond in susceptible beta-lactam antibiotics, thus conferring resistance to penicillins and cephalosporins. TEM-3 and TEM-4 are capable of hydrolyzing cefotaxime and ceftazidime. TEM-5 is capable of hydrolyzing ceftazidime. TEM-6 is capable of hydrolyzing ceftazidime and aztreonam. TEM-8/CAZ-2, TEM-16/CAZ-7 and TEM-24/CAZ-6 are markedly active against ceftazidime. IRT-4 shows resistance to beta-lactamase inhibitors. | |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
| Line 25: | Line 25: | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Escherichia coli]] |
| - | + | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: New Delhi Metallo-b-Lactamase]] | [[Category: New Delhi Metallo-b-Lactamase]] | ||
[[Category: RCSB PDB Molecule of the Month]] | [[Category: RCSB PDB Molecule of the Month]] | ||
| - | [[Category: Massova | + | [[Category: Massova I]] |
| - | [[Category: Maveyraud | + | [[Category: Maveyraud L]] |
| - | [[Category: Mobashery | + | [[Category: Mobashery S]] |
| - | [[Category: Samama | + | [[Category: Samama JP]] |
| - | + | ||
| - | + | ||
| - | + | ||
Current revision
6 ALPHA HYDROXYMETHYL PENICILLOIC ACID ACYLATED ON THE TEM-1 BETA-LACTAMASE FROM ESCHERICHIA COLI
| |||||||||||
