8j9s

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'''Unreleased structure'''
 
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The entry 8j9s is ON HOLD until Paper Publication
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==leucine zipper complex of AIMP1 and AIMP2==
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<StructureSection load='8j9s' size='340' side='right'caption='[[8j9s]], [[Resolution|resolution]] 3.01&Aring;' scene=''>
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Authors: Kim, D.K., Kang, B.S.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8j9s]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8J9S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8J9S FirstGlance]. <br>
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Description: leucine zipper complex of AIMP1 and AIMP2
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.01&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>
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[[Category: Kang, B.S]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8j9s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8j9s OCA], [https://pdbe.org/8j9s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8j9s RCSB], [https://www.ebi.ac.uk/pdbsum/8j9s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8j9s ProSAT]</span></td></tr>
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[[Category: Kim, D.K]]
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/AIMP1_HUMAN AIMP1_HUMAN] Defects in AIMP1 are the cause of leukodystrophy hypomyelinating type 3 (HLD3) [MIM:[https://omim.org/entry/260600 260600]. A severe autosomal recessive hypomyelinating leukodystrophy characterized by early infantile onset of global developmental delay, lack of development, lack of speech acquisition, and peripheral spasticity associated with decreased myelination in the central nervous system.<ref>PMID:21092922</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/AIMP1_HUMAN AIMP1_HUMAN] Non-catalytic component of the multisynthase complex. Stimulates the catalytic activity of cytoplasmic arginyl-tRNA synthase. Binds tRNA. Possesses inflammatory cytokine activity. Negatively regulates TGF-beta signaling through stabilization of SMURF2 by binding to SMURF2 and inhibiting its SMAD7-mediated degradation. Involved in glucose homeostasis through induction of glucagon secretion at low glucose levels. Promotes dermal fibroblast proliferation and wound repair. Regulates KDELR1-mediated retention of HSP90B1/gp96 in the endoplasmic reticulum. Plays a role in angiogenesis by inducing endothelial cell migration at low concentrations and endothelian cell apoptosis at high concentrations. Induces maturation of dendritic cells and monocyte cell adhesion. Modulates endothelial cell responses by degrading HIF-1A through interaction with PSMA7.<ref>PMID:10358004</ref> <ref>PMID:11306575</ref> <ref>PMID:12237313</ref> <ref>PMID:11818442</ref> <ref>PMID:19362550</ref> <ref>PMID:11157763</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Kang BS]]
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[[Category: Kim DK]]

Revision as of 08:28, 9 May 2024

leucine zipper complex of AIMP1 and AIMP2

PDB ID 8j9s

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