8owy
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of METTL6 mutant 40-269 bound to SAH== | |
| - | + | <StructureSection load='8owy' size='340' side='right'caption='[[8owy]], [[Resolution|resolution]] 3.20Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8owy]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8OWY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8OWY FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8owy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8owy OCA], [https://pdbe.org/8owy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8owy RCSB], [https://www.ebi.ac.uk/pdbsum/8owy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8owy ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/METL6_HUMAN METL6_HUMAN] S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA(Ser), including tRNA(Ser)(UGA) and tRNA(Ser)(GCU) (PubMed:32923617, PubMed:34922197, PubMed:34268557, PubMed:34862464). Interaction with SARS1/SerRS is required for N(3)-methylcytidine methylation (PubMed:34268557).<ref>PMID:32923617</ref> <ref>PMID:34268557</ref> <ref>PMID:34862464</ref> <ref>PMID:34922197</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Basu S]] | ||
| + | [[Category: Dolce LG]] | ||
| + | [[Category: Kowalinski E]] | ||
| + | [[Category: Throll P]] | ||
Revision as of 08:32, 9 May 2024
Crystal structure of METTL6 mutant 40-269 bound to SAH
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