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8umu

From Proteopedia

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m (Protected "8umu" [edit=sysop:move=sysop])
Current revision (08:37, 9 May 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 8umu is ON HOLD until Paper Publication
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==Atomic model of the human CTF18-RFC-PCNA binary complex in the four-subunit binding state (state 3)==
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<StructureSection load='8umu' size='340' side='right'caption='[[8umu]], [[Resolution|resolution]] 3.16&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8umu]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8UMU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8UMU FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.16&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=AGS:PHOSPHOTHIOPHOSPHORIC+ACID-ADENYLATE+ESTER'>AGS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8umu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8umu OCA], [https://pdbe.org/8umu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8umu RCSB], [https://www.ebi.ac.uk/pdbsum/8umu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8umu ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CTF18_HUMAN CTF18_HUMAN] Chromosome cohesion factor involved in sister chromatid cohesion and fidelity of chromosome transmission. Component of one of the cell nuclear antigen loader complexes, CTF18-replication factor C (CTF18-RFC), which consists of CTF18, CTF8, DCC1, RFC2, RFC3, RFC4 and RFC5. The CTF18-RFC complex binds to single-stranded and primed DNAs and has weak ATPase activity that is stimulated by the presence of primed DNA, replication protein A (RPA) and by proliferating cell nuclear antigen (PCNA). The CTF18-RFC complex catalyzes the ATP-dependent loading of PCNA onto primed and gapped DNA. Interacts with and stimulates DNA polymerase POLH. During DNA repair synthesis, involved in loading DNA polymerase POLE at the sites of local damage (PubMed:20227374).<ref>PMID:12766176</ref> <ref>PMID:12930902</ref> <ref>PMID:17545166</ref> <ref>PMID:20227374</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: He Q]]
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[[Category: Li H]]
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[[Category: Wang F]]

Current revision

Atomic model of the human CTF18-RFC-PCNA binary complex in the four-subunit binding state (state 3)

PDB ID 8umu

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OCA

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