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2uxc

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Current revision (09:52, 9 May 2024) (edit) (undo)
 
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<StructureSection load='2uxc' size='340' side='right'caption='[[2uxc]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
<StructureSection load='2uxc' size='340' side='right'caption='[[2uxc]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2uxc]] is a 23 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UXC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2UXC FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2uxc]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus_HB8 Thermus thermophilus HB8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UXC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2UXC FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PAR:PAROMOMYCIN'>PAR</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2uxb|2uxb]], [[2uxd|2uxd]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PAR:PAROMOMYCIN'>PAR</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2uxc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uxc OCA], [https://pdbe.org/2uxc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2uxc RCSB], [https://www.ebi.ac.uk/pdbsum/2uxc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2uxc ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2uxc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uxc OCA], [https://pdbe.org/2uxc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2uxc RCSB], [https://www.ebi.ac.uk/pdbsum/2uxc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2uxc ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/RS16_THET8 RS16_THET8]] Binds to the lower part of the body of the 30S subunit, where it stabilizes two of its domains.[HAMAP-Rule:MF_00385] [[https://www.uniprot.org/uniprot/RS6_THET8 RS6_THET8]] Located on the outer edge of the platform on the body of the 30S subunit.[HAMAP-Rule:MF_00360] [[https://www.uniprot.org/uniprot/RS9_THET8 RS9_THET8]] Part of the top of the head of the 30S subunit. The C-terminal region penetrates the head emerging in the P-site where it contacts tRNA.[HAMAP-Rule:MF_00532_B] [[https://www.uniprot.org/uniprot/RS8_THET8 RS8_THET8]] One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit central domain. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.[HAMAP-Rule:MF_01302_B]
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[https://www.uniprot.org/uniprot/RS2_THET8 RS2_THET8] Spans the head-body hinge region of the 30S subunit. Is loosely associated with the 30S subunit.[HAMAP-Rule:MF_00291_B]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Thermus thermophilus]]
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[[Category: Thermus thermophilus HB8]]
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[[Category: Dunham, C M]]
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[[Category: Dunham CM]]
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[[Category: Joseph, S]]
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[[Category: Joseph S]]
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[[Category: Kelley, A C]]
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[[Category: Kelley AC]]
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[[Category: Phelps, S S]]
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[[Category: Phelps SS]]
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[[Category: Ramakrishnan, V]]
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[[Category: Ramakrishnan V]]
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[[Category: Selmer, M]]
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[[Category: Selmer M]]
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[[Category: Suzuki, T]]
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[[Category: Suzuki T]]
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[[Category: 30s ribosomal subunit]]
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[[Category: A site]]
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[[Category: Anticodon]]
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[[Category: Codon]]
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[[Category: Decoding]]
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[[Category: Frameshift]]
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[[Category: Frameshift suppressor trna]]
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[[Category: Messenger rna]]
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[[Category: Metal-binding]]
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[[Category: Mrna]]
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[[Category: Paromomycin]]
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[[Category: Ribonucleoprotein]]
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[[Category: Ribosomal protein]]
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[[Category: Ribosome]]
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[[Category: Rna- binding]]
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[[Category: Rna-binding]]
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[[Category: Rrna-binding]]
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[[Category: Stem-loop]]
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[[Category: Transfer rna]]
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[[Category: Trna]]
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[[Category: Trna-binding]]
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[[Category: Zinc-finger]]
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Current revision

Crystal structure of an extended tRNA anticodon stem loop in complex with its cognate mRNA UCGU in the context of the Thermus thermophilus 30S subunit.

PDB ID 2uxc

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