1rz8

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[[Image:1rz8.gif|left|200px]]
[[Image:1rz8.gif|left|200px]]
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{{Structure
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|PDB= 1rz8 |SIZE=350|CAPTION= <scene name='initialview01'>1rz8</scene>, resolution 2.30&Aring;
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The line below this paragraph, containing "STRUCTURE_1rz8", creates the "Structure Box" on the page.
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{{STRUCTURE_1rz8| PDB=1rz8 | SCENE= }}
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|RELATEDENTRY=[[1rz7|1RZ7]], [[1rzf|1RZF]], [[1rzg|1RZG]], [[1rzi|1RZI]], [[1rzj|1RZJ]], [[1rzk|1RZK]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rz8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rz8 OCA], [http://www.ebi.ac.uk/pdbsum/1rz8 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1rz8 RCSB]</span>
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}}
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'''CRYSTAL STRUCTURE OF HUMAN ANTI-HIV-1 GP120-REACTIVE ANTIBODY 17B'''
'''CRYSTAL STRUCTURE OF HUMAN ANTI-HIV-1 GP120-REACTIVE ANTIBODY 17B'''
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==About this Structure==
==About this Structure==
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1RZ8 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RZ8 OCA].
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RZ8 OCA].
==Reference==
==Reference==
Structural basis of tyrosine sulfation and VH-gene usage in antibodies that recognize the HIV type 1 coreceptor-binding site on gp120., Huang CC, Venturi M, Majeed S, Moore MJ, Phogat S, Zhang MY, Dimitrov DS, Hendrickson WA, Robinson J, Sodroski J, Wyatt R, Choe H, Farzan M, Kwong PD, Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):2706-11. Epub 2004 Feb 23. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14981267 14981267]
Structural basis of tyrosine sulfation and VH-gene usage in antibodies that recognize the HIV type 1 coreceptor-binding site on gp120., Huang CC, Venturi M, Majeed S, Moore MJ, Phogat S, Zhang MY, Dimitrov DS, Hendrickson WA, Robinson J, Sodroski J, Wyatt R, Choe H, Farzan M, Kwong PD, Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):2706-11. Epub 2004 Feb 23. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14981267 14981267]
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[[Category: Homo sapiens]]
 
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[[Category: Protein complex]]
 
[[Category: Choe, H.]]
[[Category: Choe, H.]]
[[Category: Dimitrov, D S.]]
[[Category: Dimitrov, D S.]]
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[[Category: Wyatt, R.]]
[[Category: Wyatt, R.]]
[[Category: Zhang, M Y.]]
[[Category: Zhang, M Y.]]
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[[Category: antibody]]
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[[Category: Antibody]]
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[[Category: cd4i]]
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[[Category: Cd4i]]
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[[Category: gp120]]
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[[Category: Gp120]]
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[[Category: hiv-1]]
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[[Category: Hiv-1]]
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[[Category: tyrosine sulfation]]
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[[Category: Tyrosine sulfation]]
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[[Category: vh-gene usage]]
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[[Category: Vh-gene usage]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:05:41 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:35:06 2008''
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Revision as of 05:05, 3 May 2008

Image:1rz8.gif

Template:STRUCTURE 1rz8

CRYSTAL STRUCTURE OF HUMAN ANTI-HIV-1 GP120-REACTIVE ANTIBODY 17B


Overview

The conserved surface of the HIV-1 gp120 envelope glycoprotein that binds to the HIV-1 coreceptor is protected from humoral recognition by multiple layers of camouflage. Here we present sequence and genomic analyses for 12 antibodies that pierce these defenses and determine the crystal structures of 5. The data reveal mechanisms and atomic-level details for three unusual immune features: posttranslational mimicry of coreceptor by tyrosine sulfation of antibody, an alternative molecular mechanism controlling such sulfation, and highly selective V(H)-gene usage. When confronted by extraordinary viral defenses, the immune system unveils novel adaptive capabilities, with tyrosine sulfation enhancing the vocabulary of antigen recognition.

About this Structure

Full crystallographic information is available from OCA.

Reference

Structural basis of tyrosine sulfation and VH-gene usage in antibodies that recognize the HIV type 1 coreceptor-binding site on gp120., Huang CC, Venturi M, Majeed S, Moore MJ, Phogat S, Zhang MY, Dimitrov DS, Hendrickson WA, Robinson J, Sodroski J, Wyatt R, Choe H, Farzan M, Kwong PD, Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):2706-11. Epub 2004 Feb 23. PMID:14981267 Page seeded by OCA on Sat May 3 08:05:41 2008

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