2wo8

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Current revision (10:15, 9 May 2024) (edit) (undo)
 
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<StructureSection load='2wo8' size='340' side='right'caption='[[2wo8]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
<StructureSection load='2wo8' size='340' side='right'caption='[[2wo8]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2wo8]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WO8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WO8 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2wo8]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WO8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WO8 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=023:N^2^-[(2R)-2-{(1S)-1-[FORMYL(HYDROXY)AMINO]ETHYL}-5-PHENYLPENTANOYL]-N,3-DIMETHYL-L-VALINAMIDE'>023</scene>, <scene name='pdbligand=077:(3S)-5-BIPHENYL-4-YL-3-HYDROXYPENTANOIC+ACID'>077</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1ycm|1ycm]], [[2woa|2woa]], [[1os9|1os9]], [[1utt|1utt]], [[1y93|1y93]], [[1z3j|1z3j]], [[2w0d|2w0d]], [[1os2|1os2]], [[2wo9|2wo9]], [[1jk3|1jk3]], [[1ros|1ros]], [[1utz|1utz]], [[1rmz|1rmz]], [[1jiz|1jiz]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=023:N^2^-[(2R)-2-{(1S)-1-[FORMYL(HYDROXY)AMINO]ETHYL}-5-PHENYLPENTANOYL]-N,3-DIMETHYL-L-VALINAMIDE'>023</scene>, <scene name='pdbligand=077:(3S)-5-BIPHENYL-4-YL-3-HYDROXYPENTANOIC+ACID'>077</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Macrophage_elastase Macrophage elastase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.65 3.4.24.65] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wo8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wo8 OCA], [https://pdbe.org/2wo8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wo8 RCSB], [https://www.ebi.ac.uk/pdbsum/2wo8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wo8 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wo8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wo8 OCA], [https://pdbe.org/2wo8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wo8 RCSB], [https://www.ebi.ac.uk/pdbsum/2wo8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wo8 ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MMP12_HUMAN MMP12_HUMAN] May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Macrophage elastase]]
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[[Category: Amour AJ]]
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[[Category: Amour, A J]]
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[[Category: Baddeley SJ]]
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[[Category: Baddeley, S J]]
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[[Category: Brown D]]
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[[Category: Brown, D]]
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[[Category: Convery MA]]
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[[Category: Convery, M A]]
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[[Category: Egan D]]
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[[Category: Egan, D]]
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[[Category: Gaines S]]
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[[Category: Gaines, S]]
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[[Category: Gross JW]]
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[[Category: Gross, J W]]
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[[Category: Herbert S]]
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[[Category: Herbert, S]]
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[[Category: Holmes IP]]
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[[Category: Holmes, I P]]
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[[Category: Lorthioir O]]
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[[Category: Lorthioir, O]]
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[[Category: Martin SL]]
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[[Category: Martin, S L]]
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[[Category: Singh OMP]]
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[[Category: Singh, O M.P]]
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[[Category: Smith RH]]
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[[Category: Smith, R H]]
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[[Category: Strelow JM]]
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[[Category: Strelow, J M]]
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[[Category: Walker A]]
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[[Category: Walker, A]]
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[[Category: Watson SP]]
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[[Category: Watson, S P]]
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[[Category: Extracellular matrix]]
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[[Category: Glycoprotein]]
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[[Category: Hydrolase]]
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[[Category: Matrix metalloprotease mmp-12 complex structure]]
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[[Category: Metal-binding]]
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[[Category: Metalloprotease]]
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[[Category: Polymorphism]]
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[[Category: Protease]]
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[[Category: Secreted]]
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[[Category: Zymogen]]
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Current revision

MMP12 complex with a beta hydroxy carboxylic acid

PDB ID 2wo8

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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