2wwb

From Proteopedia

(Difference between revisions)

Current revision

CRYO-EM STRUCTURE OF THE MAMMALIAN SEC61 COMPLEX BOUND TO THE ACTIVELY TRANSLATING WHEAT GERM 80S RIBOSOME

2wwb, resolution 6.48Å

Structural highlights

2wwb is a 10 chain structure with sequence from Canis lupus familiaris and Triticum aestivum. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	Electron Microscopy, Resolution 6.48Å
Experimental data:	Check to display Experimental Data
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

S61A1_CANLF

Evolutionary Conservation

Checkto colour the structure by Evolutionary Conservation, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

The trimeric Sec61/SecY complex is a protein-conducting channel (PCC) for secretory and membrane proteins. Although Sec complexes can form oligomers, it has been suggested that a single copy may serve as an active PCC. We determined subnanometer-resolution cryo-electron microscopy structures of eukaryotic ribosome-Sec61 complexes. In combination with biochemical data, we found that in both idle and active states, the Sec complex is not oligomeric and interacts mainly via two cytoplasmic loops with the universal ribosomal adaptor site. In the active state, the ribosomal tunnel and a central pore of the monomeric PCC were occupied by the nascent chain, contacting loop 6 of the Sec complex. This provides a structural basis for the activity of a solitary Sec complex in cotranslational protein translocation.

Structure of monomeric yeast and Mammalian sec61 complexes interacting with the translating ribosome.,Becker T, Bhushan S, Jarasch A, Armache JP, Funes S, Jossinet F, Gumbart J, Mielke T, Berninghausen O, Schulten K, Westhof E, Gilmore R, Mandon EC, Beckmann R Science. 2009 Dec 4;326(5958):1369-73. Epub 2009 Oct 29. PMID:19933108^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Becker T, Bhushan S, Jarasch A, Armache JP, Funes S, Jossinet F, Gumbart J, Mielke T, Berninghausen O, Schulten K, Westhof E, Gilmore R, Mandon EC, Beckmann R. Structure of monomeric yeast and Mammalian sec61 complexes interacting with the translating ribosome. Science. 2009 Dec 4;326(5958):1369-73. Epub 2009 Oct 29. PMID:19933108

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 See Also
6 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2wwb"

@@ Line 3: / Line 3: @@
 <SX load='2wwb' size='340' side='right' viewer='molstar' caption='[[2wwb]], [[Resolution|resolution]] 6.48&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2wwb]] is a 15 chain structure with sequence from [https://en.wikipedia.org/wiki/Canis_lupus_familiaris Canis lupus familiaris] and [https://en.wikipedia.org/wiki/Triticum_aestivum Triticum aestivum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WWB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WWB FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2wwb]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Canis_lupus_familiaris Canis lupus familiaris] and [https://en.wikipedia.org/wiki/Triticum_aestivum Triticum aestivum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WWB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WWB FirstGlance]. <br>
-</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1k5y|1k5y]], [[1s1i|1s1i]], [[2wwa|2wwa]]</div></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 6.48&#8491;</td></tr>
 <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wwb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wwb OCA], [https://pdbe.org/2wwb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wwb RCSB], [https://www.ebi.ac.uk/pdbsum/2wwb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wwb ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/S61A1_CANLF S61A1_CANLF]
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
@@ Line 43: / Line 45: @@
 [[Category: Large Structures]]
 [[Category: Triticum aestivum]]
-[[Category: Armache, J P]]
+[[Category: Armache JP]]
-[[Category: Becker, T]]
+[[Category: Becker T]]
-[[Category: Beckmann, R]]
+[[Category: Beckmann R]]
-[[Category: Berninghausen, O]]
+[[Category: Berninghausen O]]
-[[Category: Bhushan, S]]
+[[Category: Bhushan S]]
-[[Category: Funes, S]]
+[[Category: Funes S]]
-[[Category: Gilmore, R]]
+[[Category: Gilmore R]]
-[[Category: Gumbart, J]]
+[[Category: Gumbart J]]
-[[Category: Jarasch, A]]
+[[Category: Jarasch A]]
-[[Category: Jossinet, F]]
+[[Category: Jossinet F]]
-[[Category: Mandon, E]]
+[[Category: Mandon E]]
-[[Category: Mielke, T]]
+[[Category: Mielke T]]
-[[Category: Schulten, K]]
+[[Category: Schulten K]]
-[[Category: Westhof, E]]
+[[Category: Westhof E]]
-[[Category: Cotranslational protein translocation]]
-[[Category: Protein conducting channel]]
-[[Category: Protein exit tunnel]]
-[[Category: Ribosome]]
-[[Category: Signal sequence]]

2wwb

From Proteopedia

Current revision

CRYO-EM STRUCTURE OF THE MAMMALIAN SEC61 COMPLEX BOUND TO THE ACTIVELY TRANSLATING WHEAT GERM 80S RIBOSOME

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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