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2x4m

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Current revision (10:21, 9 May 2024) (edit) (undo)
 
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<StructureSection load='2x4m' size='340' side='right'caption='[[2x4m]], [[Resolution|resolution]] 2.55&Aring;' scene=''>
<StructureSection load='2x4m' size='340' side='right'caption='[[2x4m]], [[Resolution|resolution]] 2.55&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2x4m]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_pestis"_(lehmann_and_neumann_1896)_migula_1900 "bacillus pestis" (lehmann and neumann 1896) migula 1900]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X4M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2X4M FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2x4m]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Yersinia_pestis Yersinia pestis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X4M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2X4M FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C8E:(HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE'>C8E</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.55&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2x55|2x55]], [[2x56|2x56]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C8E:(HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE'>C8E</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Plasminogen_activator_Pla Plasminogen activator Pla], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.48 3.4.23.48] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2x4m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x4m OCA], [https://pdbe.org/2x4m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2x4m RCSB], [https://www.ebi.ac.uk/pdbsum/2x4m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2x4m ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2x4m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x4m OCA], [https://pdbe.org/2x4m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2x4m RCSB], [https://www.ebi.ac.uk/pdbsum/2x4m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2x4m ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/COLY_YERPE COLY_YERPE]] Seems to play an essential role in plague transmission by mediating flea blockage in a temperature-dependent fashion. Fibrinolytic activity prevails at 37 degrees Celsius whereas coagulase expression predominates at lower temperatures (<30 degrees Celsius). Activates plasminogen by cleaving it.
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[https://www.uniprot.org/uniprot/COLY_YERPE COLY_YERPE] Seems to play an essential role in plague transmission by mediating flea blockage in a temperature-dependent fashion. Fibrinolytic activity prevails at 37 degrees Celsius whereas coagulase expression predominates at lower temperatures (<30 degrees Celsius). Activates plasminogen by cleaving it.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Plasminogen activator Pla]]
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[[Category: Yersinia pestis]]
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[[Category: Berg, B van den]]
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[[Category: Eren E]]
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[[Category: Eren, E]]
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[[Category: Goguen J]]
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[[Category: Goguen, J]]
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[[Category: Murphy M]]
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[[Category: Murphy, M]]
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[[Category: Van den Berg B]]
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[[Category: Aspartyl protease]]
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[[Category: Cell outer membrane]]
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[[Category: Hydrolase]]
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[[Category: Omptin]]
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[[Category: Protease]]
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[[Category: Transmembrane]]
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Current revision

Yersinia Pestis Plasminogen Activator Pla

PDB ID 2x4m

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OCA

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