Epidermal growth factor receptor substrate
From Proteopedia
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== Function == | == Function == | ||
| - | '''Epidermal growth factor receptor substrate 8''' (Eps8) is a substrate for receptor tyrosine kinases<ref>PMID:8404850</ref> | + | '''Epidermal growth factor receptor substrate 8''' (Eps8) is a substrate for receptor tyrosine kinases<ref>PMID:8404850</ref>. Eps8 i overexpressed in human pituitary tumors<ref>PMID:19116338</ref>. Eps8 has a role in amplifying growth factor signaling in human pituitary tumors to promote proliferation and cell survival. Eps8 enable actin binding activity and small GTPase binding activity. |
== Disease == | == Disease == | ||
== Relevance == | == Relevance == | ||
| + | |||
| + | Eps8 overexpressing ells are protected from serum withdrawal-induced apoptosis. | ||
== Structural highlights == | == Structural highlights == | ||
Revision as of 10:23, 9 May 2024
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References
- ↑ Fazioli F, Minichiello L, Matoska V, Castagnino P, Miki T, Wong WT, Di Fiore PP. Eps8, a substrate for the epidermal growth factor receptor kinase, enhances EGF-dependent mitogenic signals. EMBO J. 1993 Oct;12(10):3799-808. PMID:8404850
- ↑ Xu M, Shorts-Cary L, Knox AJ, Kleinsmidt-DeMasters B, Lillehei K, Wierman ME. Epidermal growth factor receptor pathway substrate 8 is overexpressed in human pituitary tumors: role in proliferation and survival. Endocrinology. 2009 May;150(5):2064-71. PMID:19116338 doi:10.1210/en.2008-1265
