2xct

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Current revision (10:24, 9 May 2024) (edit) (undo)
 
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<StructureSection load='2xct' size='340' side='right'caption='[[2xct]], [[Resolution|resolution]] 3.35&Aring;' scene=''>
<StructureSection load='2xct' size='340' side='right'caption='[[2xct]], [[Resolution|resolution]] 3.35&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2xct]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Staan Staan]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XCT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XCT FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2xct]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_N315 Staphylococcus aureus subsp. aureus N315] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XCT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XCT FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CPF:1-CYCLOPROPYL-6-FLUORO-4-OXO-7-PIPERAZIN-1-YL-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC+ACID'>CPF</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.35&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2xcs|2xcs]], [[2xco|2xco]], [[2xcq|2xcq]], [[2xcr|2xcr]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CPF:1-CYCLOPROPYL-6-FLUORO-4-OXO-7-PIPERAZIN-1-YL-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC+ACID'>CPF</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/DNA_topoisomerase_(ATP-hydrolyzing) DNA topoisomerase (ATP-hydrolyzing)], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.99.1.3 5.99.1.3] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xct FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xct OCA], [https://pdbe.org/2xct PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xct RCSB], [https://www.ebi.ac.uk/pdbsum/2xct PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xct ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xct FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xct OCA], [https://pdbe.org/2xct PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xct RCSB], [https://www.ebi.ac.uk/pdbsum/2xct PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xct ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/GYRB_STAAN GYRB_STAAN]] DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity).
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[https://www.uniprot.org/uniprot/GYRA_STAAN GYRA_STAAN] DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings.[HAMAP-Rule:MF_01897][https://www.uniprot.org/uniprot/GYRB_STAAN GYRB_STAAN] DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Staan]]
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[[Category: Staphylococcus aureus subsp. aureus N315]]
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[[Category: Bax, B D]]
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[[Category: Synthetic construct]]
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[[Category: Brown, K K]]
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[[Category: Bax BD]]
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[[Category: Chan, P]]
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[[Category: Brown KK]]
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[[Category: Eggleston, D S]]
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[[Category: Chan P]]
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[[Category: Fosberry, A]]
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[[Category: Eggleston DS]]
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[[Category: Gentry, D R]]
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[[Category: Fosberry A]]
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[[Category: Giordano, I]]
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[[Category: Gentry DR]]
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[[Category: Gorrec, F]]
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[[Category: Giordano I]]
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[[Category: Gwynn, M N]]
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[[Category: Gorrec F]]
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[[Category: Hann, M M]]
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[[Category: Gwynn MN]]
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[[Category: Hennessy, A]]
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[[Category: Hann MM]]
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[[Category: Hibbs, M]]
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[[Category: Hennessy A]]
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[[Category: Huang, J]]
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[[Category: Hibbs M]]
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[[Category: Jones, E]]
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[[Category: Huang J]]
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[[Category: Jones, J]]
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[[Category: Jones E]]
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[[Category: Lewis, C J]]
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[[Category: Jones J]]
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[[Category: May, E]]
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[[Category: Lewis CJ]]
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[[Category: Pearson, N D]]
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[[Category: May E]]
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[[Category: Shen, C]]
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[[Category: Pearson ND]]
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[[Category: Shillings, A]]
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[[Category: Shen C]]
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[[Category: Singh, O]]
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[[Category: Shillings A]]
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[[Category: Spitzfaden, C]]
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[[Category: Singh O]]
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[[Category: Theobald, A]]
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[[Category: Spitzfaden C]]
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[[Category: Wohlkonig, A]]
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[[Category: Theobald A]]
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[[Category: Isomerase-dna-antibiotic complex]]
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[[Category: Wohlkonig A]]

Current revision

The twinned 3.35A structure of S. aureus Gyrase complex with Ciprofloxacin and DNA

PDB ID 2xct

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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