2xq3

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Current revision (10:28, 9 May 2024) (edit) (undo)
 
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<StructureSection load='2xq3' size='340' side='right'caption='[[2xq3]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
<StructureSection load='2xq3' size='340' side='right'caption='[[2xq3]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2xq3]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Glovi Glovi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XQ3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XQ3 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2xq3]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Gloeobacter_violaceus_PCC_7421 Gloeobacter violaceus PCC 7421]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XQ3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XQ3 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.5&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2xqa|2xqa]], [[2xq9|2xq9]], [[2xq7|2xq7]], [[2xq5|2xq5]], [[2xq8|2xq8]], [[2xq4|2xq4]], [[2xq6|2xq6]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xq3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xq3 OCA], [https://pdbe.org/2xq3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xq3 RCSB], [https://www.ebi.ac.uk/pdbsum/2xq3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xq3 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xq3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xq3 OCA], [https://pdbe.org/2xq3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xq3 RCSB], [https://www.ebi.ac.uk/pdbsum/2xq3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xq3 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/GLIC_GLOVI GLIC_GLOVI]] Cationic channel with similar permeabilities for Na(+) and K(+), that is activated by an increase of the proton concentration on the extracellular side. Displays no permeability for chloride ions. Shows slow kinetics of activation, no desensitization and a single channel conductance of 8 pS. Might contribute to adaptation to external pH change.<ref>PMID:17167423</ref>
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[https://www.uniprot.org/uniprot/GLIC_GLOVI GLIC_GLOVI] Cationic channel with similar permeabilities for Na(+) and K(+), that is activated by an increase of the proton concentration on the extracellular side. Displays no permeability for chloride ions. Shows slow kinetics of activation, no desensitization and a single channel conductance of 8 pS. Might contribute to adaptation to external pH change.<ref>PMID:17167423</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Glovi]]
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[[Category: Gloeobacter violaceus PCC 7421]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Bertozzi, C]]
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[[Category: Bertozzi C]]
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[[Category: Dutzler, R]]
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[[Category: Dutzler R]]
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[[Category: Hilf, R J.C]]
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[[Category: Hilf RJC]]
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[[Category: Reiter, A]]
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[[Category: Reiter A]]
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[[Category: Trauner, D]]
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[[Category: Trauner D]]
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[[Category: Zimmermann, I]]
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[[Category: Zimmermann I]]
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[[Category: Membrane protein]]
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[[Category: Open channel block]]
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Current revision

Pentameric ligand gated ion channel GLIC in complex with Br-lidocaine

PDB ID 2xq3

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