3zue
From Proteopedia
(Difference between revisions)
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<SX load='3zue' size='340' side='right' viewer='molstar' caption='[[3zue]], [[Resolution|resolution]] 10.30Å' scene=''> | <SX load='3zue' size='340' side='right' viewer='molstar' caption='[[3zue]], [[Resolution|resolution]] 10.30Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
- | <table><tr><td colspan='2'>[[3zue]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[3zue]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Rabbit_hemorrhagic_disease_virus Rabbit hemorrhagic disease virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZUE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZUE FirstGlance]. <br> |
- | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zue FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zue OCA], [https://pdbe.org/3zue PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zue RCSB], [https://www.ebi.ac.uk/pdbsum/3zue PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zue ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 10.3Å</td></tr> |
+ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zue FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zue OCA], [https://pdbe.org/3zue PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zue RCSB], [https://www.ebi.ac.uk/pdbsum/3zue PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zue ProSAT]</span></td></tr> | ||
</table> | </table> | ||
+ | == Function == | ||
+ | [https://www.uniprot.org/uniprot/POLG_RHDVA POLG_RHDVA] NTPase presumably plays a role in replication. Viral genome-linked protein is covalently linked to the 5'-end of the positive-strand, negative-strand genomic RNAs and subgenomic RNA. Acts as a genome-linked replication primer. May recruit ribosome to viral RNA thereby promoting viral proteins translation (By similarity). 3C-like protease processes the polyprotein: 3CLpro-RdRp (p72) is first released by autocleavage, then all other proteins are cleaved. RNA-directed RNA polymerase replicates genomic and antigenomic RNA by recognizing replications specific signals. Transcribes also a subgenomic mRNA by initiating RNA synthesis internally on antigenomic RNA. This sgRNA codes for structural proteins. Catalyzes the covalent attachment VPg with viral RNAs (By similarity).[PROSITE-ProRule:PRU00539] Capsid protein VP60 self assembles to form an icosahedral capsid with a T=3 symmetry, about 35 nm in diameter, and consisting of 180 capsid proteins. A smaller form of capsid with a diameter of 23 nm might be capsid proteins assembled as icosahedron with T=1 symmetry. The capsid encapsulate VP2 proteins and genomic or subgenomic RNA. Attaches virion to target cells by binding histo-blood group antigens, inducing endocytosis of the viral particle. Acidification of the endosome induces conformational change of capsid protein thereby injecting virus genomic RNA into host cytoplasm (By similarity). | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</SX> | </SX> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
- | [[Category: | + | [[Category: Rabbit hemorrhagic disease virus]] |
- | [[Category: Angulo | + | [[Category: Angulo I]] |
- | [[Category: Barcena | + | [[Category: Barcena J]] |
- | [[Category: Carrascosa | + | [[Category: Carrascosa JL]] |
- | [[Category: Caston | + | [[Category: Caston JR]] |
- | [[Category: Chichon | + | [[Category: Chichon J]] |
- | [[Category: Gomez-Blanco | + | [[Category: Gomez-Blanco J]] |
- | [[Category: Gonzalez | + | [[Category: Gonzalez JM]] |
- | [[Category: Luque | + | [[Category: Luque D]] |
- | [[Category: Marabini | + | [[Category: Marabini R]] |
- | [[Category: Mena | + | [[Category: Mena I]] |
- | [[Category: Trus | + | [[Category: Trus BL]] |
- | [[Category: Verdaguer | + | [[Category: Verdaguer N]] |
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Current revision
Rabbit Hemorrhagic Disease Virus (RHDV)capsid protein
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