3zys

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Current revision (10:44, 9 May 2024) (edit) (undo)
 
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<SX load='3zys' size='340' side='right' viewer='molstar' caption='[[3zys]], [[Resolution|resolution]] 12.20&Aring;' scene=''>
<SX load='3zys' size='340' side='right' viewer='molstar' caption='[[3zys]], [[Resolution|resolution]] 12.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3zys]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZYS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZYS FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3zys]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZYS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZYS FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3zyc|3zyc]], [[2x2f|2x2f]], [[2dyn|2dyn]], [[2x2e|2x2e]], [[1dyn|1dyn]]</div></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 12.2&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Dynamin_GTPase Dynamin GTPase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.5.5 3.6.5.5] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zys FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zys OCA], [https://pdbe.org/3zys PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zys RCSB], [https://www.ebi.ac.uk/pdbsum/3zys PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zys ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zys FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zys OCA], [https://pdbe.org/3zys PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zys RCSB], [https://www.ebi.ac.uk/pdbsum/3zys PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zys ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/DYN1_HUMAN DYN1_HUMAN]] Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Involved in receptor-mediated endocytosis. [[https://www.uniprot.org/uniprot/MX1_HUMAN MX1_HUMAN]] Interferon-induced dynamin-like GTPase with antiviral activity against a wide range of RNA viruses and some DNA viruses. Its target viruses include negative-stranded RNA viruses and HBV through binding and inactivation of their ribonucleocapsid. May also antagonize reoviridae and asfarviridae replication. Inhibits thogoto virus (THOV) replication by preventing the nuclear import of viral nucleocapsids. Inhibits La Crosse virus (LACV) replication by sequestering viral nucleoprotein in perinuclear complexes, preventing genome amplification, budding, and egress. Inhibits influenza A virus (IAV) replication by decreasing or delaying NP synthesis and by blocking endocytic traffic of incoming virus particles. Enhances ER stress-mediated cell death after influenza virus infection. May regulate the calcium channel activity of TRPCs.<ref>PMID:20603636</ref> <ref>PMID:11880649</ref> <ref>PMID:15047845</ref> <ref>PMID:14752052</ref> <ref>PMID:15355513</ref> <ref>PMID:14687945</ref> <ref>PMID:15757897</ref> <ref>PMID:16413306</ref> <ref>PMID:16202617</ref> <ref>PMID:17374778</ref> <ref>PMID:18668195</ref> <ref>PMID:19109387</ref> <ref>PMID:21900240</ref> <ref>PMID:21992152</ref>
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[https://www.uniprot.org/uniprot/DYN1_HUMAN DYN1_HUMAN] Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Involved in receptor-mediated endocytosis.
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== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
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[[Category: Dynamin GTPase]]
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[[Category: Homo sapiens]]
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[[Category: Human]]
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[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Chappie, J S]]
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[[Category: Chappie JS]]
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[[Category: Dyda, F]]
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[[Category: Dyda F]]
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[[Category: Fang, S]]
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[[Category: Fang S]]
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[[Category: Hinshaw, J E]]
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[[Category: Hinshaw JE]]
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[[Category: Leonard, M]]
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[[Category: Leonard M]]
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[[Category: Mears, J A]]
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[[Category: Mears JA]]
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[[Category: Milligan, R A]]
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[[Category: Milligan RA]]
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[[Category: Schmid, S L]]
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[[Category: Schmid SL]]
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[[Category: Endocytosis]]
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[[Category: Gtp hydrolysis]]
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[[Category: Hydrolase-gtp-binding protein complex]]
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[[Category: Membrane remodeling]]
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Current revision

Human dynamin 1 deltaPRD polymer stabilized with GMPPCP

3zys, resolution 12.20Å

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