4ajd

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Current revision (10:50, 9 May 2024) (edit) (undo)
 
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<StructureSection load='4ajd' size='340' side='right'caption='[[4ajd]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
<StructureSection load='4ajd' size='340' side='right'caption='[[4ajd]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4ajd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AJD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AJD FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4ajd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AJD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AJD FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=F04:2-ETHYL-4-METHYL-PHTHALAZIN-1-ONE'>F04</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1lrb|1lrb]], [[2wey|2wey]], [[2y0j|2y0j]], [[4ael|4ael]], [[4ajf|4ajf]], [[4ajg|4ajg]], [[4ajm|4ajm]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=F04:2-ETHYL-4-METHYL-PHTHALAZIN-1-ONE'>F04</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ajd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ajd OCA], [https://pdbe.org/4ajd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ajd RCSB], [https://www.ebi.ac.uk/pdbsum/4ajd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ajd ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ajd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ajd OCA], [https://pdbe.org/4ajd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ajd RCSB], [https://www.ebi.ac.uk/pdbsum/4ajd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ajd ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/PDE10_HUMAN PDE10_HUMAN]] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.<ref>PMID:17389385</ref>
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[https://www.uniprot.org/uniprot/PDE10_HUMAN PDE10_HUMAN] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.<ref>PMID:17389385</ref>
==See Also==
==See Also==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Aharony, D]]
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[[Category: Aharony D]]
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[[Category: Akerud, T]]
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[[Category: Akerud T]]
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[[Category: Albert, J S]]
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[[Category: Albert JS]]
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[[Category: Back, E]]
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[[Category: Back E]]
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[[Category: Geschwindner, S]]
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[[Category: Geschwindner S]]
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[[Category: Hillertz, P]]
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[[Category: Hillertz P]]
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[[Category: Horsefeld, R]]
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[[Category: Horsefeld R]]
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[[Category: Johansson, P]]
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[[Category: Johansson P]]
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[[Category: Scott, C]]
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[[Category: Scott C]]
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[[Category: Spadola, L]]
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[[Category: Spadola L]]
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[[Category: Spear, N]]
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[[Category: Spear N]]
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[[Category: Tian, G]]
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[[Category: Tian G]]
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[[Category: Tigerstrom, A]]
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[[Category: Tigerstrom A]]
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[[Category: Hydrolase]]
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Current revision

Identification and structural characterization of PDE10 fragment inhibitors

PDB ID 4ajd

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