4bqg
From Proteopedia
(Difference between revisions)
| Line 3: | Line 3: | ||
<StructureSection load='4bqg' size='340' side='right'caption='[[4bqg]], [[Resolution|resolution]] 1.90Å' scene=''> | <StructureSection load='4bqg' size='340' side='right'caption='[[4bqg]], [[Resolution|resolution]] 1.90Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4bqg]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BQG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BQG FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[4bqg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BQG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BQG FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=50Q:5-(3,4-DICHLORO-PHENOXY)-BENZENE-1,3-DIOL'>50Q</scene></td></tr> |
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bqg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bqg OCA], [https://pdbe.org/4bqg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bqg RCSB], [https://www.ebi.ac.uk/pdbsum/4bqg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bqg ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bqg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bqg OCA], [https://pdbe.org/4bqg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bqg RCSB], [https://www.ebi.ac.uk/pdbsum/4bqg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bqg ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
| Line 24: | Line 26: | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Amboldi | + | [[Category: Amboldi N]] |
| - | [[Category: Bindi | + | [[Category: Bindi S]] |
| - | [[Category: Brasca | + | [[Category: Brasca MG]] |
| - | [[Category: Caronni | + | [[Category: Caronni D]] |
| - | [[Category: Casale | + | [[Category: Casale E]] |
| - | [[Category: Ceccarelli | + | [[Category: Ceccarelli W]] |
| - | [[Category: Colombo | + | [[Category: Colombo N]] |
| - | [[Category: DePonti | + | [[Category: DePonti A]] |
| - | [[Category: Donati | + | [[Category: Donati D]] |
| - | [[Category: Ermoli | + | [[Category: Ermoli A]] |
| - | [[Category: Fachin | + | [[Category: Fachin G]] |
| - | [[Category: Felder | + | [[Category: Felder ER]] |
| - | [[Category: Ferguson | + | [[Category: Ferguson RD]] |
| - | [[Category: Fiorelli | + | [[Category: Fiorelli C]] |
| - | [[Category: Fogliatto | + | [[Category: Fogliatto G]] |
| - | [[Category: Guanci | + | [[Category: Guanci M]] |
| - | [[Category: Isacchi | + | [[Category: Isacchi A]] |
| - | [[Category: Mantegani | + | [[Category: Mantegani S]] |
| - | [[Category: Pesenti | + | [[Category: Pesenti E]] |
| - | [[Category: Polucci | + | [[Category: Polucci P]] |
| - | [[Category: Riceputi | + | [[Category: Riceputi L]] |
| - | [[Category: Sola | + | [[Category: Sola F]] |
| - | [[Category: Visco | + | [[Category: Visco C]] |
| - | [[Category: Zuccotto | + | [[Category: Zuccotto F]] |
| - | + | ||
Current revision
structure of HSP90 with an inhibitor bound
| |||||||||||
Categories: Homo sapiens | Large Structures | Amboldi N | Bindi S | Brasca MG | Caronni D | Casale E | Ceccarelli W | Colombo N | DePonti A | Donati D | Ermoli A | Fachin G | Felder ER | Ferguson RD | Fiorelli C | Fogliatto G | Guanci M | Isacchi A | Mantegani S | Pesenti E | Polucci P | Riceputi L | Sola F | Visco C | Zuccotto F
