4d2s

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Current revision (11:17, 9 May 2024) (edit) (undo)
 
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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4d2s]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D2S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4D2S FirstGlance]. <br>
<table><tr><td colspan='2'>[[4d2s]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D2S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4D2S FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DYK:N-{2-METHOXY-4-[(1-METHYLPIPERIDIN-4-YL)OXY]PHENYL}-4-(1H-PYRROLO[2,3-C]PYRIDIN-3-YL)PYRIMIDIN-2-AMINE'>DYK</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DYK:N-{2-METHOXY-4-[(1-METHYLPIPERIDIN-4-YL)OXY]PHENYL}-4-(1H-PYRROLO[2,3-C]PYRIDIN-3-YL)PYRIMIDIN-2-AMINE'>DYK</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4d2s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d2s OCA], [https://pdbe.org/4d2s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4d2s RCSB], [https://www.ebi.ac.uk/pdbsum/4d2s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4d2s ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4d2s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d2s OCA], [https://pdbe.org/4d2s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4d2s RCSB], [https://www.ebi.ac.uk/pdbsum/4d2s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4d2s ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/TTK_HUMAN TTK_HUMAN]] Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.<ref>PMID:18243099</ref>
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[https://www.uniprot.org/uniprot/TTK_HUMAN TTK_HUMAN] Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.<ref>PMID:18243099</ref>
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== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==

Current revision

Human TTK in complex with a Dyrk1B inhibitor

PDB ID 4d2s

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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