6fkp

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==Crystal structure of BAZ2A PHD zinc finger in complex with H3 10-mer AA mutant peptide==
==Crystal structure of BAZ2A PHD zinc finger in complex with H3 10-mer AA mutant peptide==
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<StructureSection load='6fkp' size='340' side='right' caption='[[6fkp]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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<StructureSection load='6fkp' size='340' side='right'caption='[[6fkp]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6fkp]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FKP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FKP FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6fkp]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FKP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6FKP FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BAZ2A, KIAA0314, TIP5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6fkp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fkp OCA], [http://pdbe.org/6fkp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6fkp RCSB], [http://www.ebi.ac.uk/pdbsum/6fkp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6fkp ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6fkp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fkp OCA], [https://pdbe.org/6fkp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6fkp RCSB], [https://www.ebi.ac.uk/pdbsum/6fkp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6fkp ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/BAZ2A_HUMAN BAZ2A_HUMAN]] Essential component of the NoRC (nucleolar remodeling complex) complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing. In the complex, it plays a central role by being recruited to rDNA and by targeting chromatin modifying enzymes such as HDAC1, leading to repress RNA polymerase I transcription. Recruited to rDNA via its interaction with TTF1 and its ability to recognize and bind histone H4 acetylated on 'Lys-16' (H4K16ac), leading to deacetylation of H4K5ac, H4K8ac, H4K12ac but not H4K16ac. Specifically binds pRNAs, 150-250 nucleotide RNAs that are complementary in sequence to the rDNA promoter; pRNA-binding is required for heterochromatin formation and rDNA silencing (By similarity).
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[https://www.uniprot.org/uniprot/BAZ2A_HUMAN BAZ2A_HUMAN] Essential component of the NoRC (nucleolar remodeling complex) complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing. In the complex, it plays a central role by being recruited to rDNA and by targeting chromatin modifying enzymes such as HDAC1, leading to repress RNA polymerase I transcription. Recruited to rDNA via its interaction with TTF1 and its ability to recognize and bind histone H4 acetylated on 'Lys-16' (H4K16ac), leading to deacetylation of H4K5ac, H4K8ac, H4K12ac but not H4K16ac. Specifically binds pRNAs, 150-250 nucleotide RNAs that are complementary in sequence to the rDNA promoter; pRNA-binding is required for heterochromatin formation and rDNA silencing (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6fkp" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6fkp" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Bromodomain adjacent to zinc finger 3D structures|Bromodomain adjacent to zinc finger 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Amato, A]]
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[[Category: Large Structures]]
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[[Category: Bortoluzzi, A]]
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[[Category: Amato A]]
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[[Category: Ciulli, A]]
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[[Category: Bortoluzzi A]]
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[[Category: Lucas, X]]
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[[Category: Ciulli A]]
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[[Category: Wright, D]]
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[[Category: Lucas X]]
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[[Category: Baz2a]]
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[[Category: Wright D]]
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[[Category: Bromodomain]]
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[[Category: Epigenetic]]
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[[Category: H3]]
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[[Category: Histone]]
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[[Category: Phd zinc finger]]
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[[Category: Transcription]]
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Current revision

Crystal structure of BAZ2A PHD zinc finger in complex with H3 10-mer AA mutant peptide

PDB ID 6fkp

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