1w6h
From Proteopedia
(Difference between revisions)
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<StructureSection load='1w6h' size='340' side='right'caption='[[1w6h]], [[Resolution|resolution]] 2.24Å' scene=''> | <StructureSection load='1w6h' size='340' side='right'caption='[[1w6h]], [[Resolution|resolution]] 2.24Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[1w6h]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[1w6h]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W6H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1W6H FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TIT:N-((3S,4S)-5-[(4-BROMOBENZYL)OXY]-3-HYDROXY-4-{[N-(PYRIDIN-2-YLCARBONYL)-L-VALYL]AMINO}PENTANOYL)-L-ALANYL-L-LEUCINAMIDE'>TIT</scene | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.24Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TIT:N-((3S,4S)-5-[(4-BROMOBENZYL)OXY]-3-HYDROXY-4-{[N-(PYRIDIN-2-YLCARBONYL)-L-VALYL]AMINO}PENTANOYL)-L-ALANYL-L-LEUCINAMIDE'>TIT</scene></td></tr> | |
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1w6h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w6h OCA], [https://pdbe.org/1w6h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1w6h RCSB], [https://www.ebi.ac.uk/pdbsum/1w6h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1w6h ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1w6h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w6h OCA], [https://pdbe.org/1w6h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1w6h RCSB], [https://www.ebi.ac.uk/pdbsum/1w6h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1w6h ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/PLM2_PLAFX PLM2_PLAFX] During the asexual blood stage, participates in initial cleavage of native host hemoglobin (Hb) resulting in Hb denaturation (PubMed:8844673, PubMed:11782538, PubMed:15574427). May cleave preferentially denatured hemoglobin that has been cleaved by PMI (PubMed:8844673). Digestion of host Hb is an essential step which provides the parasite with amino acids for protein synthesis, and regulates osmolarity (Probable).<ref>PMID:11782538</ref> <ref>PMID:15574427</ref> <ref>PMID:8844673</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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==See Also== | ==See Also== | ||
*[[Plasmepsin|Plasmepsin]] | *[[Plasmepsin|Plasmepsin]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: | + | [[Category: Plasmodium falciparum]] |
| - | + | [[Category: Johansson P-O]] | |
| - | [[Category: Johansson | + | [[Category: Kvarnstroem I]] |
| - | [[Category: Kvarnstroem | + | [[Category: Lindberg J]] |
| - | [[Category: Lindberg | + | [[Category: Rosenquist A]] |
| - | [[Category: Rosenquist | + | [[Category: Samuelsson B]] |
| - | [[Category: Samuelsson | + | [[Category: Unge T]] |
| - | [[Category: Unge | + | [[Category: Vrang L]] |
| - | [[Category: Vrang | + | |
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Revision as of 13:31, 9 May 2024
Novel plasmepsin II-inhibitor complex
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