1wck

From Proteopedia

(Difference between revisions)

Revision as of 13:33, 9 May 2024

Crystal structure of the C-terminal domain of BclA, the major antigen of the exosporium of the Bacillus anthracis spore.

Structural highlights

1wck is a 1 chain structure with sequence from Bacillus anthracis. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 1.36Å
Ligands:
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

Q83WB0_BACAN

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

The lethal disease anthrax is propagated by spores of Bacillus anthracis, which can penetrate into the mammalian host by inhalation, causing a rapid progression of the disease and a mostly fatal outcome. We have solved the three-dimensional structure of the major surface protein BclA on B. anthracis spores. Surprisingly, the structure resembles C1q, the first component of complement, despite there being no sequence homology. Although most assays for C1q-like activity, including binding to C1q receptors, suggest that BclA does not mimic C1q, we show that BclA, as well as C1q, interacts with components of the lung alveolar surfactant layer. Thus, to better recognize and invade its hosts, this pathogenic soil bacterium may have evolved a surface protein whose structure is strikingly close to a mammalian protein.

The crystal structure of the Bacillus anthracis spore surface protein BclA shows remarkable similarity to mammalian proteins.,Rety S, Salamitou S, Garcia-Verdugo I, Hulmes DJ, Le Hegarat F, Chaby R, Lewit-Bentley A J Biol Chem. 2005 Dec 30;280(52):43073-8. Epub 2005 Oct 25. PMID:16249180^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Rety S, Salamitou S, Garcia-Verdugo I, Hulmes DJ, Le Hegarat F, Chaby R, Lewit-Bentley A. The crystal structure of the Bacillus anthracis spore surface protein BclA shows remarkable similarity to mammalian proteins. J Biol Chem. 2005 Dec 30;280(52):43073-8. Epub 2005 Oct 25. PMID:16249180 doi:10.1074/jbc.M510087200

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1wck"

@@ Line 3: / Line 3: @@
 <StructureSection load='1wck' size='340' side='right'caption='[[1wck]], [[Resolution|resolution]] 1.36&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1wck]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_cereus_var._anthracis"_(cohn_1872)_smith_et_al._1946 "bacillus cereus var. anthracis" (cohn 1872) smith et al. 1946]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WCK OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1WCK FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1wck]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WCK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WCK FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.36&#8491;</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1wck FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wck OCA], [http://pdbe.org/1wck PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1wck RCSB], [http://www.ebi.ac.uk/pdbsum/1wck PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1wck ProSAT]</span></td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wck FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wck OCA], [https://pdbe.org/1wck PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wck RCSB], [https://www.ebi.ac.uk/pdbsum/1wck PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wck ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/Q83WB0_BACAN Q83WB0_BACAN]
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
@@ Line 30: / Line 33: @@
 __TOC__
 </StructureSection>
+[[Category: Bacillus anthracis]]
 [[Category: Large Structures]]
-[[Category: Augusto, L A]]
+[[Category: Augusto LA]]
-[[Category: Chaby, R]]
+[[Category: Chaby R]]
-[[Category: Lehegarat, F]]
+[[Category: Lehegarat F]]
-[[Category: Lewit-Bentley, A]]
+[[Category: Lewit-Bentley A]]
-[[Category: Rety, S]]
+[[Category: Rety S]]
-[[Category: Salamitou, S]]
+[[Category: Salamitou S]]
-[[Category: Bacterial surface antigen]]
-[[Category: Collagen-like protein]]
-[[Category: Jelly-roll topology]]
-[[Category: Structural protein]]

1wck

From Proteopedia

Revision as of 13:33, 9 May 2024

Crystal structure of the C-terminal domain of BclA, the major antigen of the exosporium of the Bacillus anthracis spore.

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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