1wfl
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
==Solution structure of the zf-AN1 domain from mouse zinc finger protein 216== | ==Solution structure of the zf-AN1 domain from mouse zinc finger protein 216== | ||
| - | <StructureSection load='1wfl' size='340' side='right'caption='[[1wfl | + | <StructureSection load='1wfl' size='340' side='right'caption='[[1wfl]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[1wfl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[1wfl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WFL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WFL FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wfl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wfl OCA], [https://pdbe.org/1wfl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wfl RCSB], [https://www.ebi.ac.uk/pdbsum/1wfl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wfl ProSAT], [https://www.topsan.org/Proteins/RSGI/1wfl TOPSAN]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wfl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wfl OCA], [https://pdbe.org/1wfl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wfl RCSB], [https://www.ebi.ac.uk/pdbsum/1wfl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wfl ProSAT], [https://www.topsan.org/Proteins/RSGI/1wfl TOPSAN]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/ZFAN5_MOUSE ZFAN5_MOUSE] Involved in protein degradation via the ubiquitin-proteasome system. May act by anchoring ubiquitinated proteins to the proteasome. Plays a role in ubiquitin-mediated protein degradation during muscle atrophy. Plays a role in the regulation of NF-kappa-B activation and apoptosis. Inhibits NF-kappa-B activation triggered by overexpression of RIPK1 and TRAF6 but not of RELA. Inhibits also tumor necrosis factor (TNF), IL-1 and TLR4-induced NF-kappa-B activation in a dose-dependent manner. Overexpression sensitizes cells to TNF-induced apoptosis. Is a potent inhibitory factor for osteoclast differentiation.<ref>PMID:16194934</ref> <ref>PMID:16424905</ref> | |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
| Line 25: | Line 25: | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: | + | [[Category: Mus musculus]] |
| - | [[Category: Inoue | + | [[Category: Inoue M]] |
| - | [[Category: Kigawa | + | [[Category: Kigawa T]] |
| - | [[Category: Koshiba | + | [[Category: Koshiba S]] |
| - | + | [[Category: Tomizawa T]] | |
| - | [[Category: Tomizawa | + | [[Category: Yokoyama S]] |
| - | [[Category: Yokoyama | + | |
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
Current revision
Solution structure of the zf-AN1 domain from mouse zinc finger protein 216
| |||||||||||
