1whv

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Current revision (13:40, 9 May 2024) (edit) (undo)
 
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==Solution structure of the RNA binding domain from hypothetical protein BAB23382==
==Solution structure of the RNA binding domain from hypothetical protein BAB23382==
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<StructureSection load='1whv' size='340' side='right'caption='[[1whv]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='1whv' size='340' side='right'caption='[[1whv]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1whv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WHV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WHV FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1whv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WHV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WHV FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RIKEN CDNA 1200003I18 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1whv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1whv OCA], [https://pdbe.org/1whv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1whv RCSB], [https://www.ebi.ac.uk/pdbsum/1whv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1whv ProSAT], [https://www.topsan.org/Proteins/RSGI/1whv TOPSAN]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1whv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1whv OCA], [https://pdbe.org/1whv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1whv RCSB], [https://www.ebi.ac.uk/pdbsum/1whv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1whv ProSAT], [https://www.topsan.org/Proteins/RSGI/1whv TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/PARN_MOUSE PARN_MOUSE]] 3'-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs and is also used to silence certain maternal mRNAs translationally during oocyte maturation and early embryonic development. Interacts with both the 3'-end poly(A) tail and the 5'-end cap structure during degradation, the interaction with the cap structure being required for an efficient degradation of poly(A) tails. Involved in nonsense-mediated mRNA decay, a critical process of selective degradation of mRNAs that contain premature stop codons. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly via its interaction with KHSRP. Probably mediates the removal of poly(A) tails of AREs mRNAs, which constitutes the first step of destabilization (By similarity).
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[https://www.uniprot.org/uniprot/PARN_MOUSE PARN_MOUSE] 3'-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs and is also used to silence certain maternal mRNAs translationally during oocyte maturation and early embryonic development. Interacts with both the 3'-end poly(A) tail and the 5'-end cap structure during degradation, the interaction with the cap structure being required for an efficient degradation of poly(A) tails. Involved in nonsense-mediated mRNA decay, a critical process of selective degradation of mRNAs that contain premature stop codons. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly via its interaction with KHSRP. Probably mediates the removal of poly(A) tails of AREs mRNAs, which constitutes the first step of destabilization (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Lk3 transgenic mice]]
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[[Category: Mus musculus]]
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[[Category: Inoue, M]]
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[[Category: Inoue M]]
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[[Category: Kigawa, T]]
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[[Category: Kigawa T]]
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[[Category: Muto, Y]]
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[[Category: Muto Y]]
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[[Category: Nagata, T]]
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[[Category: Nagata T]]
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[[Category: Structural genomic]]
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[[Category: Shirouzu M]]
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[[Category: Shirouzu, M]]
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[[Category: Terada T]]
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[[Category: Terada, T]]
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[[Category: Yokoyama S]]
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[[Category: Yokoyama, S]]
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[[Category: Hydrolase]]
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[[Category: Parn]]
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[[Category: Rbd]]
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[[Category: Rna binding domain]]
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[[Category: Rna recognition motif]]
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[[Category: Rnp]]
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[[Category: Rrm]]
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[[Category: Rsgi]]
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Current revision

Solution structure of the RNA binding domain from hypothetical protein BAB23382

PDB ID 1whv

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Proteopedia Page Contributors and Editors (what is this?)

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