1wxb

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==Solution structure of the SH3 domain from human epidermal growth factor receptor pathway substrate 8-like protein==
==Solution structure of the SH3 domain from human epidermal growth factor receptor pathway substrate 8-like protein==
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<StructureSection load='1wxb' size='340' side='right'caption='[[1wxb]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='1wxb' size='340' side='right'caption='[[1wxb]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1wxb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WXB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WXB FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1wxb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WXB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WXB FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">EPS8L2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wxb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wxb OCA], [https://pdbe.org/1wxb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wxb RCSB], [https://www.ebi.ac.uk/pdbsum/1wxb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wxb ProSAT], [https://www.topsan.org/Proteins/RSGI/1wxb TOPSAN]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wxb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wxb OCA], [https://pdbe.org/1wxb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wxb RCSB], [https://www.ebi.ac.uk/pdbsum/1wxb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wxb ProSAT], [https://www.topsan.org/Proteins/RSGI/1wxb TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/ES8L2_HUMAN ES8L2_HUMAN]] Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton.<ref>PMID:14565974</ref>
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[https://www.uniprot.org/uniprot/ES8L2_HUMAN ES8L2_HUMAN] Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton.<ref>PMID:14565974</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Chikayama, E]]
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[[Category: Chikayama E]]
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[[Category: Inoue, M]]
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[[Category: Inoue M]]
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[[Category: Kigawa, T]]
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[[Category: Kigawa T]]
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[[Category: Koshiba, S]]
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[[Category: Koshiba S]]
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[[Category: Muto, Y]]
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[[Category: Muto Y]]
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[[Category: Structural genomic]]
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[[Category: Yokoyama S]]
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[[Category: Yokoyama, S]]
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[[Category: Eps8]]
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[[Category: Eps8l2]]
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[[Category: National project on protein structural and functional analyse]]
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[[Category: Nppsfa]]
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[[Category: Rsgi]]
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[[Category: Sh3]]
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[[Category: Unknown function]]
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Revision as of 13:52, 9 May 2024

Solution structure of the SH3 domain from human epidermal growth factor receptor pathway substrate 8-like protein

PDB ID 1wxb

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