1wxs

From Proteopedia

(Difference between revisions)

Current revision

Solution Structure of Ufm1, a ubiquitin-fold modifier

Structural highlights

1wxs is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	Solution NMR
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

UFM1_HUMAN Ubiquitin-like modifier protein which binds to a number of target proteins, such as DDRGK1.^[1] ^[2]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

The ubiquitin-fold modifier 1 (Ufm1) is one of various ubiquitin-like modifiers and conjugates to target proteins in cells through Uba5 (E1) and Ufc1 (E2). The Ufm1-system is conserved in metazoa and plants, suggesting its potential roles in various multicellular organisms. Herein, we analyzed the solution structure and dynamics of human Ufm1 (hsUfm1) by nuclear magnetic resonance spectroscopy. Although the global fold of hsUfm1 is similar to those of ubiquitin (Ub) and NEDD8, the cluster of acidic residues conserved in Ub and NEDD8 does not exist on the Ufm1 surface. 15N spin relaxation data revealed that the amino acid residues of hsUfm1 exhibiting conformational fluctuations form a cluster at the C-terminal segment and its spatial proximity, which correspond to the versatile ligand-binding sites of Ub and other ubiquitin-like proteins (Ubls). We suggest that Ub and other Ubl-modifiers share a common feature of potential conformational multiplicity, which might be associated with the broad ligand specificities of these proteins.

Solution structure and dynamics of Ufm1, a ubiquitin-fold modifier 1.,Sasakawa H, Sakata E, Yamaguchi Y, Komatsu M, Tatsumi K, Kominami E, Tanaka K, Kato K Biochem Biophys Res Commun. 2006 Apr 28;343(1):21-6. Epub 2006 Feb 28. PMID:16527251^[3]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Komatsu M, Chiba T, Tatsumi K, Iemura S, Tanida I, Okazaki N, Ueno T, Kominami E, Natsume T, Tanaka K. A novel protein-conjugating system for Ufm1, a ubiquitin-fold modifier. EMBO J. 2004 May 5;23(9):1977-86. Epub 2004 Apr 8. PMID:15071506 doi:http://dx.doi.org/10.1038/sj.emboj.7600205
↑ Tatsumi K, Sou YS, Tada N, Nakamura E, Iemura S, Natsume T, Kang SH, Chung CH, Kasahara M, Kominami E, Yamamoto M, Tanaka K, Komatsu M. A novel type of E3 ligase for the Ufm1 conjugation system. J Biol Chem. 2010 Feb 19;285(8):5417-27. doi: 10.1074/jbc.M109.036814. Epub 2009 , Dec 14. PMID:20018847 doi:http://dx.doi.org/10.1074/jbc.M109.036814
↑ Sasakawa H, Sakata E, Yamaguchi Y, Komatsu M, Tatsumi K, Kominami E, Tanaka K, Kato K. Solution structure and dynamics of Ufm1, a ubiquitin-fold modifier 1. Biochem Biophys Res Commun. 2006 Apr 28;343(1):21-6. Epub 2006 Feb 28. PMID:16527251 doi:10.1016/j.bbrc.2006.02.107

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 See Also
6 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1wxs"

@@ Line 1: / Line 1: @@
 ==Solution Structure of Ufm1, a ubiquitin-fold modifier==
-<StructureSection load='1wxs' size='340' side='right'caption='[[1wxs]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
+<StructureSection load='1wxs' size='340' side='right'caption='[[1wxs]]' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1wxs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WXS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WXS FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1wxs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WXS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WXS FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wxs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wxs OCA], [https://pdbe.org/1wxs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wxs RCSB], [https://www.ebi.ac.uk/pdbsum/1wxs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wxs ProSAT]</span></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wxs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wxs OCA], [https://pdbe.org/1wxs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wxs RCSB], [https://www.ebi.ac.uk/pdbsum/1wxs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wxs ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[https://www.uniprot.org/uniprot/UFM1_HUMAN UFM1_HUMAN]] Ubiquitin-like modifier protein which binds to a number of target proteins, such as DDRGK1.<ref>PMID:15071506</ref> <ref>PMID:20018847</ref>
+[https://www.uniprot.org/uniprot/UFM1_HUMAN UFM1_HUMAN] Ubiquitin-like modifier protein which binds to a number of target proteins, such as DDRGK1.<ref>PMID:15071506</ref> <ref>PMID:20018847</ref>
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
@@ Line 29: / Line 30: @@
 ==See Also==
-*[[Ubiquitin-fold modifier|Ubiquitin-fold modifier]]
+*[[Ubiquitin-fold modifier 3D structures|Ubiquitin-fold modifier 3D structures]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Human]]
+[[Category: Homo sapiens]]
 [[Category: Large Structures]]
-[[Category: Kato, K]]
+[[Category: Kato K]]
-[[Category: Komatsu, M]]
+[[Category: Komatsu M]]
-[[Category: Kominami, E]]
+[[Category: Kominami E]]
-[[Category: Sakata, E]]
+[[Category: Sakata E]]
-[[Category: Sasakawa, H]]
+[[Category: Sasakawa H]]
-[[Category: Tanaka, K]]
+[[Category: Tanaka K]]
-[[Category: Tatsumi, K]]
+[[Category: Tatsumi K]]
-[[Category: Yamaguchi, Y]]
+[[Category: Yamaguchi Y]]
-[[Category: Structural genomic]]
-[[Category: Ubiquitin-fold]]
-[[Category: Unknown function]]

1wxs

From Proteopedia

Current revision

Solution Structure of Ufm1, a ubiquitin-fold modifier

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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