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1wz0

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==Solution Structure of Human SUMO-2 (SMT3B), a Ubiquitin-like Protein==
==Solution Structure of Human SUMO-2 (SMT3B), a Ubiquitin-like Protein==
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<StructureSection load='1wz0' size='340' side='right'caption='[[1wz0]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='1wz0' size='340' side='right'caption='[[1wz0]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1wz0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WZ0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WZ0 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1wz0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WZ0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WZ0 FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SMT3B ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wz0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wz0 OCA], [https://pdbe.org/1wz0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wz0 RCSB], [https://www.ebi.ac.uk/pdbsum/1wz0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wz0 ProSAT], [https://www.topsan.org/Proteins/RSGI/1wz0 TOPSAN]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wz0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wz0 OCA], [https://pdbe.org/1wz0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wz0 RCSB], [https://www.ebi.ac.uk/pdbsum/1wz0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wz0 ProSAT], [https://www.topsan.org/Proteins/RSGI/1wz0 TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/SUMO2_HUMAN SUMO2_HUMAN]] Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins.<ref>PMID:9556629</ref> <ref>PMID:18538659</ref> <ref>PMID:18408734</ref>
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[https://www.uniprot.org/uniprot/SUMO2_HUMAN SUMO2_HUMAN] Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins.<ref>PMID:9556629</ref> <ref>PMID:18538659</ref> <ref>PMID:18408734</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wz0 ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wz0 ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
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==See Also==
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*[[SUMO 3D Structures|SUMO 3D Structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Inoue, M]]
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[[Category: Inoue M]]
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[[Category: Kigawa, T]]
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[[Category: Kigawa T]]
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[[Category: Koshiba, S]]
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[[Category: Koshiba S]]
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[[Category: Structural genomic]]
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[[Category: Saito K]]
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[[Category: Saito, K]]
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[[Category: Yokoyama S]]
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[[Category: Yokoyama, S]]
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[[Category: Zhao C]]
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[[Category: Zhao, C]]
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[[Category: Nppfsa]]
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[[Category: Rsgi]]
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[[Category: Sentrin2]]
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[[Category: Sumo-2]]
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[[Category: Ubiquitin-like molecule]]
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[[Category: Unknown function]]
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Current revision

Solution Structure of Human SUMO-2 (SMT3B), a Ubiquitin-like Protein

PDB ID 1wz0

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