1x48
From Proteopedia
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==Solution structure of the second DSRM domain in Interferon-induced, double-stranded RNA-activated protein kinase== | ==Solution structure of the second DSRM domain in Interferon-induced, double-stranded RNA-activated protein kinase== | ||
| - | <StructureSection load='1x48' size='340' side='right'caption='[[1x48 | + | <StructureSection load='1x48' size='340' side='right'caption='[[1x48]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[1x48]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[1x48]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X48 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1X48 FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1x48 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x48 OCA], [https://pdbe.org/1x48 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1x48 RCSB], [https://www.ebi.ac.uk/pdbsum/1x48 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1x48 ProSAT], [https://www.topsan.org/Proteins/RSGI/1x48 TOPSAN]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1x48 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x48 OCA], [https://pdbe.org/1x48 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1x48 RCSB], [https://www.ebi.ac.uk/pdbsum/1x48 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1x48 ProSAT], [https://www.topsan.org/Proteins/RSGI/1x48 TOPSAN]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/E2AK2_MOUSE E2AK2_MOUSE] Following activation by double-stranded RNA in the presence of ATP, the kinase becomes autophosphorylated and can catalyze the phosphorylation of the translation initiation factor EIF2S1, which leads to an inhibition of the initiation of protein synthesis. Double-stranded RNA is generated during the course of a viral infection. In addition to serine/threonine-protein kinase activity, also has tyrosine-protein kinase activity: phosphorylates CDK1 upon DNA damage. CDK1 phosphorylation triggers CDK1 polyubiquitination and subsequent proteolysis, thus leading to G2 arrest (By similarity). | |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: | + | [[Category: Mus musculus]] |
| - | [[Category: He | + | [[Category: He F]] |
| - | [[Category: Inoue | + | [[Category: Inoue M]] |
| - | [[Category: Kigawa | + | [[Category: Kigawa T]] |
| - | [[Category: Muto | + | [[Category: Muto Y]] |
| - | + | [[Category: Shirouzu M]] | |
| - | [[Category: Shirouzu | + | [[Category: Tarada T]] |
| - | [[Category: Tarada | + | [[Category: Yokoyama S]] |
| - | [[Category: Yokoyama | + | |
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Current revision
Solution structure of the second DSRM domain in Interferon-induced, double-stranded RNA-activated protein kinase
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Categories: Large Structures | Mus musculus | He F | Inoue M | Kigawa T | Muto Y | Shirouzu M | Tarada T | Yokoyama S
