1x6e

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==Solution structures of the C2H2 type zinc finger domain of human Zinc finger protein 24==
==Solution structures of the C2H2 type zinc finger domain of human Zinc finger protein 24==
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<StructureSection load='1x6e' size='340' side='right'caption='[[1x6e]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='1x6e' size='340' side='right'caption='[[1x6e]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1x6e]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X6E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1X6E FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1x6e]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X6E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1X6E FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ZNF24 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1x6e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x6e OCA], [https://pdbe.org/1x6e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1x6e RCSB], [https://www.ebi.ac.uk/pdbsum/1x6e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1x6e ProSAT], [https://www.topsan.org/Proteins/RSGI/1x6e TOPSAN]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1x6e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x6e OCA], [https://pdbe.org/1x6e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1x6e RCSB], [https://www.ebi.ac.uk/pdbsum/1x6e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1x6e ProSAT], [https://www.topsan.org/Proteins/RSGI/1x6e TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/ZNF24_HUMAN ZNF24_HUMAN]] Transcription factor required for myelination of differentiated oligodendrocytes. Required for the conversion of oligodendrocytes from the premyelinating to the myelinating state. In the developing central nervous system (CNS), involved in the maintenance in the progenitor stage by promoting the cell cycle. Specifically binds to the 5'-TCAT-3' DNA sequence (By similarity). Has transcription repressor activity in vitro.<ref>PMID:10585455</ref>
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[https://www.uniprot.org/uniprot/ZNF24_HUMAN ZNF24_HUMAN] Transcription factor required for myelination of differentiated oligodendrocytes. Required for the conversion of oligodendrocytes from the premyelinating to the myelinating state. In the developing central nervous system (CNS), involved in the maintenance in the progenitor stage by promoting the cell cycle. Specifically binds to the 5'-TCAT-3' DNA sequence (By similarity). Has transcription repressor activity in vitro.<ref>PMID:10585455</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Inoue, M]]
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[[Category: Inoue M]]
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[[Category: Kigawa, T]]
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[[Category: Kigawa T]]
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[[Category: Koshiba, S]]
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[[Category: Koshiba S]]
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[[Category: Structural genomic]]
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[[Category: Sato M]]
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[[Category: Sato, M]]
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[[Category: Tomizawa T]]
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[[Category: Tomizawa, T]]
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[[Category: Yokoyama S]]
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[[Category: Yokoyama, S]]
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[[Category: Dna binding protein]]
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[[Category: Kox17]]
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[[Category: National project on protein structural and functional analyse]]
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[[Category: Nppsfa]]
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[[Category: Rsgi]]
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[[Category: Zinc finger]]
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[[Category: Znf191]]
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[[Category: Znf24]]
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[[Category: Zscan3]]
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Current revision

Solution structures of the C2H2 type zinc finger domain of human Zinc finger protein 24

PDB ID 1x6e

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