1x7a

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 4: Line 4:
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1x7a]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X7A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1X7A FirstGlance]. <br>
<table><tr><td colspan='2'>[[1x7a]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X7A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1X7A FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=187:1-{3-[AMINO(IMINO)METHYL]PHENYL}-N-[4-(1H-BENZIMIDAZOL-1-YL)-2-FLUOROPHENYL]-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-5-CARBOXAMIDE'>187</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1pfx|1pfx]]</div></td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=187:1-{3-[AMINO(IMINO)METHYL]PHENYL}-N-[4-(1H-BENZIMIDAZOL-1-YL)-2-FLUOROPHENYL]-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-5-CARBOXAMIDE'>187</scene></td></tr>
-
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Coagulation_factor_IXa Coagulation factor IXa], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.22 3.4.21.22] </span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1x7a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x7a OCA], [https://pdbe.org/1x7a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1x7a RCSB], [https://www.ebi.ac.uk/pdbsum/1x7a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1x7a ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1x7a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x7a OCA], [https://pdbe.org/1x7a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1x7a RCSB], [https://www.ebi.ac.uk/pdbsum/1x7a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1x7a ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
-
[[https://www.uniprot.org/uniprot/FA9_PIG FA9_PIG]] Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa.
+
[https://www.uniprot.org/uniprot/FA9_PIG FA9_PIG] Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Line 37: Line 36:
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Coagulation factor IXa]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Sus scrofa]]
[[Category: Sus scrofa]]
-
[[Category: Alexander, R S]]
+
[[Category: Alexander RS]]
-
[[Category: Barbera, F]]
+
[[Category: Barbera F]]
-
[[Category: Burdick, D]]
+
[[Category: Burdick D]]
-
[[Category: Luettgen, J M]]
+
[[Category: Luettgen JM]]
-
[[Category: Nakajima, S]]
+
[[Category: Nakajima S]]
-
[[Category: Rossi, K A]]
+
[[Category: Rossi KA]]
-
[[Category: Smallheer, J M]]
+
[[Category: Smallheer JM]]
-
[[Category: Smallwood, A M]]
+
[[Category: Smallwood AM]]
-
[[Category: Wang, J]]
+
[[Category: Wang J]]
-
[[Category: Wang, S]]
+
[[Category: Wang S]]
-
[[Category: Blood clotting]]
+
-
[[Category: Hydrolase]]
+
-
[[Category: Inhibition]]
+
-
[[Category: X-ray structure]]
+

Revision as of 14:02, 9 May 2024

Porcine Factor IXa Complexed to 1-{3-[amino(imino)methyl]phenyl}-N-[4-(1H-benzimidazol-1-yl)-2-fluorophenyl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide

PDB ID 1x7a

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1x7a"
Personal tools