1s2r

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[[Image:1s2r.gif|left|200px]]
[[Image:1s2r.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1s2r |SIZE=350|CAPTION= <scene name='initialview01'>1s2r</scene>, resolution 1.53&Aring;
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The line below this paragraph, containing "STRUCTURE_1s2r", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=DA:2&#39;-DEOXYADENOSINE-5&#39;-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>, <scene name='pdbligand=SPM:SPERMINE'>SPM</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1s2r| PDB=1s2r | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1s2r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s2r OCA], [http://www.ebi.ac.uk/pdbsum/1s2r PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1s2r RCSB]</span>
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}}
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'''A High Resolution Crystal Structure of [d(CGCAAATTTGCG)]2'''
'''A High Resolution Crystal Structure of [d(CGCAAATTTGCG)]2'''
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==About this Structure==
==About this Structure==
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1S2R is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S2R OCA].
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S2R OCA].
==Reference==
==Reference==
High-resolution structure of an extended A-tract: [d(CGCAAATTTGCG)]2., Woods KK, Maehigashi T, Howerton SB, Sines CC, Tannenbaum S, Williams LD, J Am Chem Soc. 2004 Dec 1;126(47):15330-1. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15563130 15563130]
High-resolution structure of an extended A-tract: [d(CGCAAATTTGCG)]2., Woods KK, Maehigashi T, Howerton SB, Sines CC, Tannenbaum S, Williams LD, J Am Chem Soc. 2004 Dec 1;126(47):15330-1. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15563130 15563130]
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[[Category: Protein complex]]
 
[[Category: Howerton, S B.]]
[[Category: Howerton, S B.]]
[[Category: Maehigashi, T.]]
[[Category: Maehigashi, T.]]
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[[Category: Williams, L D.]]
[[Category: Williams, L D.]]
[[Category: Woods, K K.]]
[[Category: Woods, K K.]]
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[[Category: dodecamer]]
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[[Category: Dodecamer]]
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[[Category: minor groove hydration]]
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[[Category: Minor groove hydration]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:13:28 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:36:32 2008''
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Revision as of 05:13, 3 May 2008

Image:1s2r.gif

Template:STRUCTURE 1s2r

A High Resolution Crystal Structure of [d(CGCAAATTTGCG)]2


Overview

The crystal structure of [d(CGCAAATTTGCG)]2 has been determined to 1.5 A resolution, representing the first high-resolution structure of this DNA fragment. The ion interactions are novel. A spermine molecule replaces a Mg2+ observed in analogous structures. Unlike lower-resolution structures, the minor groove is narrow and the major groove lacks extra Watson-Crick hydrogen bonds. In addition, a monolayer of solvent sites, including a "spine of hydration", is visible in the minor groove. The crystal of [d(CGCAAATTTGCG)]2 was grown from a solution containing spermine, magnesium, and lithium. The conformation recapitulates that of "monovalent-minus" DNA.

About this Structure

Full crystallographic information is available from OCA.

Reference

High-resolution structure of an extended A-tract: [d(CGCAAATTTGCG)]2., Woods KK, Maehigashi T, Howerton SB, Sines CC, Tannenbaum S, Williams LD, J Am Chem Soc. 2004 Dec 1;126(47):15330-1. PMID:15563130 Page seeded by OCA on Sat May 3 08:13:28 2008

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