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1s2r
From Proteopedia
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[[Image:1s2r.gif|left|200px]] | [[Image:1s2r.gif|left|200px]] | ||
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'''A High Resolution Crystal Structure of [d(CGCAAATTTGCG)]2''' | '''A High Resolution Crystal Structure of [d(CGCAAATTTGCG)]2''' | ||
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==About this Structure== | ==About this Structure== | ||
| - | + | Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S2R OCA]. | |
==Reference== | ==Reference== | ||
High-resolution structure of an extended A-tract: [d(CGCAAATTTGCG)]2., Woods KK, Maehigashi T, Howerton SB, Sines CC, Tannenbaum S, Williams LD, J Am Chem Soc. 2004 Dec 1;126(47):15330-1. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15563130 15563130] | High-resolution structure of an extended A-tract: [d(CGCAAATTTGCG)]2., Woods KK, Maehigashi T, Howerton SB, Sines CC, Tannenbaum S, Williams LD, J Am Chem Soc. 2004 Dec 1;126(47):15330-1. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15563130 15563130] | ||
| - | [[Category: Protein complex]] | ||
[[Category: Howerton, S B.]] | [[Category: Howerton, S B.]] | ||
[[Category: Maehigashi, T.]] | [[Category: Maehigashi, T.]] | ||
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[[Category: Williams, L D.]] | [[Category: Williams, L D.]] | ||
[[Category: Woods, K K.]] | [[Category: Woods, K K.]] | ||
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| - | [[Category: | + | [[Category: Minor groove hydration]] |
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| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 05:13, 3 May 2008
A High Resolution Crystal Structure of [d(CGCAAATTTGCG)]2
Overview
The crystal structure of [d(CGCAAATTTGCG)]2 has been determined to 1.5 A resolution, representing the first high-resolution structure of this DNA fragment. The ion interactions are novel. A spermine molecule replaces a Mg2+ observed in analogous structures. Unlike lower-resolution structures, the minor groove is narrow and the major groove lacks extra Watson-Crick hydrogen bonds. In addition, a monolayer of solvent sites, including a "spine of hydration", is visible in the minor groove. The crystal of [d(CGCAAATTTGCG)]2 was grown from a solution containing spermine, magnesium, and lithium. The conformation recapitulates that of "monovalent-minus" DNA.
About this Structure
Full crystallographic information is available from OCA.
Reference
High-resolution structure of an extended A-tract: [d(CGCAAATTTGCG)]2., Woods KK, Maehigashi T, Howerton SB, Sines CC, Tannenbaum S, Williams LD, J Am Chem Soc. 2004 Dec 1;126(47):15330-1. PMID:15563130 Page seeded by OCA on Sat May 3 08:13:28 2008
