1s2x
From Proteopedia
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'''Crystal structure of Cag-Z from Helicobacter pylori''' | '''Crystal structure of Cag-Z from Helicobacter pylori''' | ||
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[[Category: Seydel, A.]] | [[Category: Seydel, A.]] | ||
[[Category: Zanotti, G.]] | [[Category: Zanotti, G.]] | ||
| - | [[Category: | + | [[Category: Cag pathogenicity island]] |
| - | [[Category: | + | [[Category: Cag-z]] |
| - | [[Category: | + | [[Category: Helicobacter pylori]] |
| - | [[Category: | + | [[Category: Type iv secretion system]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:13:47 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 05:13, 3 May 2008
Crystal structure of Cag-Z from Helicobacter pylori
Overview
CagZ, a 23 kDa protein encoded by the cagZ gene (HP0526) of the cag pathogenicity island of Helicobacter pylori, has been cloned, over-expressed, purified and its three-dimensional structure determined. The protein consists of a single compact L-shaped domain, composed of seven alpha-helices including about 70% of the total residues. Three-dimensional homology searches did not reveal structural homologues, and CagZ can be considered representative of a new protein fold. The presence of a disordered C-terminal tail and the nature of the molecular surface suggest that CagZ may participate in the interaction of effector proteins with one or more components of the H.pylori type IV secretion system on the cytoplasmic side of the inner membrane.
About this Structure
1S2X is a Single protein structure of sequence from Helicobacter pylori. Full crystallographic information is available from OCA.
Reference
Crystal structure of CagZ, a protein from the Helicobacter pylori pathogenicity island that encodes for a type IV secretion system., Cendron L, Seydel A, Angelini A, Battistutta R, Zanotti G, J Mol Biol. 2004 Jul 16;340(4):881-9. PMID:15223328 Page seeded by OCA on Sat May 3 08:13:47 2008
