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1s3t

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[[Image:1s3t.gif|left|200px]]
[[Image:1s3t.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1s3t |SIZE=350|CAPTION= <scene name='initialview01'>1s3t</scene>, resolution 2.10&Aring;
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The line below this paragraph, containing "STRUCTURE_1s3t", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=BO3:BORIC+ACID'>BO3</scene>, <scene name='pdbligand=CXM:N-CARBOXYMETHIONINE'>CXM</scene>, <scene name='pdbligand=KCX:LYSINE+NZ-CARBOXYLIC+ACID'>KCX</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Urease Urease], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.5 3.5.1.5] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1s3t| PDB=1s3t | SCENE= }}
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|RELATEDENTRY=[[1ubp|1UBP]], [[2ubp|2UBP]], [[3ubp|3UBP]], [[4ubp|4UBP]], [[1ie7|1IE7]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1s3t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s3t OCA], [http://www.ebi.ac.uk/pdbsum/1s3t PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1s3t RCSB]</span>
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}}
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'''BORATE INHIBITED BACILLUS PASTEURII UREASE CRYSTAL STRUCTURE'''
'''BORATE INHIBITED BACILLUS PASTEURII UREASE CRYSTAL STRUCTURE'''
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[[Category: Rypniewski, W R.]]
[[Category: Rypniewski, W R.]]
[[Category: Wilson, K S.]]
[[Category: Wilson, K S.]]
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[[Category: bacillus pasteurii]]
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[[Category: Bacillus pasteurii]]
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[[Category: borate]]
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[[Category: Borate]]
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[[Category: metalloenzyme]]
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[[Category: Metalloenzyme]]
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[[Category: nickel]]
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[[Category: Nickel]]
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[[Category: urease]]
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[[Category: Urease]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:15:45 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:37:00 2008''
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Revision as of 05:15, 3 May 2008

Image:1s3t.gif

Template:STRUCTURE 1s3t

BORATE INHIBITED BACILLUS PASTEURII UREASE CRYSTAL STRUCTURE


Overview

The structure of the complex of urease, a Ni-containing metalloenzyme, with boric acid was determined at 2.10 A resolution. The complex shows the unprecedented binding mode of the competitive inhibitor to the dinuclear metal center, with the B(OH)3 molecule bridging the Ni ions and leaving in place the bridging hydroxide. Boric acid can be considered a substrate analogue of urea, and the structure supports the proposal that the Ni-bridging hydroxide acts as the nucleophile in the enzymatic process of urea hydrolysis.

About this Structure

1S3T is a Protein complex structure of sequences from Sporosarcina pasteurii. Full crystallographic information is available from OCA.

Reference

Molecular details of urease inhibition by boric acid: insights into the catalytic mechanism., Benini S, Rypniewski WR, Wilson KS, Mangani S, Ciurli S, J Am Chem Soc. 2004 Mar 31;126(12):3714-5. PMID:15038715 Page seeded by OCA on Sat May 3 08:15:45 2008

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