This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.

2mkv

From Proteopedia

(Difference between revisions)

Jump to: navigation, search

Current revision

Structure of the NA,K-ATPASE regulatory protein FXYD2b in micelles

Structural highlights

2mkv is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	Solution NMR
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

ATNG_HUMAN Autosomal dominant primary hypomagnesemia with hypocalcuria. The disease is caused by mutations affecting the gene represented in this entry.

Function

ATNG_HUMAN May be involved in forming the receptor site for cardiac glycoside binding or may modulate the transport function of the sodium ATPase.

Publication Abstract from PubMed

FXYD2 is a membrane protein responsible for regulating the function of the Na,K-ATPase in mammalian kidney epithelial cells. Here we report the structure of FXYD2b, one of two splice variants of the protein, determined by NMR spectroscopy in detergent micelles. Solid-state NMR characterization of the protein embedded in phospholipid bilayers indicates that several arginine side chains may be involved in hydrogen bond interactions with the phospholipid polar head groups. The structure and the NMR data suggest that FXYD2b could regulate the Na,K-ATPase by modulating the effective membrane surface electrostatics near the ion binding sites of the pump. This article is part of a Special Issue entitled: NMR Spectroscopy for Atomistic Views of Biomembranes and Cell Surfaces.

Structure of the Na,K-ATPase regulatory protein FXYD2b in micelles: Implications for membrane-water interfacial arginines.,Gong XM, Ding Y, Yu J, Yao Y, Marassi FM Biochim Biophys Acta. 2014 May 2. pii: S0005-2736(14)00156-4. doi:, 10.1016/j.bbamem.2014.04.021. PMID:24794573^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Gong XM, Ding Y, Yu J, Yao Y, Marassi FM. Structure of the Na,K-ATPase regulatory protein FXYD2b in micelles: Implications for membrane-water interfacial arginines. Biochim Biophys Acta. 2014 May 2. pii: S0005-2736(14)00156-4. doi:, 10.1016/j.bbamem.2014.04.021. PMID:24794573 doi:http://dx.doi.org/10.1016/j.bbamem.2014.04.021

1 Structural highlights
2 Disease
3 Function
4 Publication Abstract from PubMed
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2mkv"

Categories: Homo sapiens | Large Structures | Gong X | Marassi FM

@@ Line 4: / Line 4: @@
 == Structural highlights ==
 <table><tr><td colspan='2'>[[2mkv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MKV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MKV FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mkv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mkv OCA], [https://pdbe.org/2mkv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mkv RCSB], [https://www.ebi.ac.uk/pdbsum/2mkv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mkv ProSAT]</span></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mkv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mkv OCA], [https://pdbe.org/2mkv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mkv RCSB], [https://www.ebi.ac.uk/pdbsum/2mkv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mkv ProSAT]</span></td></tr>
 </table>
 == Disease ==

2mkv

From Proteopedia

Current revision

Structure of the NA,K-ATPASE regulatory protein FXYD2b in micelles

Structural highlights

Disease

Function

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

Personal tools

Navigation

Search

Toolbox