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| | <StructureSection load='1xt5' size='340' side='right'caption='[[1xt5]], [[Resolution|resolution]] 1.15Å' scene=''> | | <StructureSection load='1xt5' size='340' side='right'caption='[[1xt5]], [[Resolution|resolution]] 1.15Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[1xt5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Amphioxus Amphioxus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XT5 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1XT5 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[1xt5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Branchiostoma_floridae Branchiostoma floridae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XT5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XT5 FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.15Å</td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">VCBP3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7739 Amphioxus])</td></tr> | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1xt5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xt5 OCA], [http://pdbe.org/1xt5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1xt5 RCSB], [http://www.ebi.ac.uk/pdbsum/1xt5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1xt5 ProSAT]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xt5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xt5 OCA], [https://pdbe.org/1xt5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xt5 RCSB], [https://www.ebi.ac.uk/pdbsum/1xt5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xt5 ProSAT]</span></td></tr> |
| | </table> | | </table> |
| | + | == Function == |
| | + | [https://www.uniprot.org/uniprot/Q8I9N0_BRAFL Q8I9N0_BRAFL] |
| | == Evolutionary Conservation == | | == Evolutionary Conservation == |
| | [[Image:Consurf_key_small.gif|200px|right]] | | [[Image:Consurf_key_small.gif|200px|right]] |
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| | __TOC__ | | __TOC__ |
| | </StructureSection> | | </StructureSection> |
| - | [[Category: Amphioxus]] | + | [[Category: Branchiostoma floridae]] |
| | [[Category: Large Structures]] | | [[Category: Large Structures]] |
| - | [[Category: Allaire, M]] | + | [[Category: Allaire M]] |
| - | [[Category: Cannon, J P]] | + | [[Category: Cannon JP]] |
| - | [[Category: Haire, R N]] | + | [[Category: Haire RN]] |
| - | [[Category: Jakoncic, J]] | + | [[Category: Hernandez Prada JA]] |
| - | [[Category: Litman, G W]] | + | [[Category: Jakoncic J]] |
| - | [[Category: Ostrov, D A]] | + | [[Category: Litman GW]] |
| - | [[Category: Prada, J A.Hernandez]] | + | [[Category: Ostrov DA]] |
| - | [[Category: Stojanoff, V]] | + | [[Category: Stojanoff V]] |
| - | [[Category: Florida lancelet]]
| + | |
| - | [[Category: Immune system]]
| + | |
| - | [[Category: Innate immunity]]
| + | |
| - | [[Category: Primordial antigen receptor]]
| + | |
| - | [[Category: Vcbp]]
| + | |
| Structural highlights
Function
Q8I9N0_BRAFL
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
Publication Abstract from PubMed
Although the origins of genes encoding the rearranging binding receptors remain obscure, it is predicted that their ancestral forms were nonrearranging immunoglobulin-type domains. Variable region-containing chitin-binding proteins (VCBPs) are diversified immune-type molecules found in amphioxus (Branchiostoma floridae), an invertebrate that diverged early in deuterostome phylogeny. To study the potential evolutionary relationships between VCBPs and vertebrate adaptive immune receptors, we solved the structures of both a single V-type domain (to 1.15 A) and a pair of V-type domains (to 1.85 A) from VCBP3. The deduced structures show integral features of the ancestral variable-region fold as well as unique features of variable-region pairing in molecules that may reflect characteristics of ancestral forms of diversified immune receptors found in modern-day vertebrates.
Ancient evolutionary origin of diversified variable regions demonstrated by crystal structures of an immune-type receptor in amphioxus.,Hernandez Prada JA, Haire RN, Allaire M, Jakoncic J, Stojanoff V, Cannon JP, Litman GW, Ostrov DA Nat Immunol. 2006 Aug;7(8):875-82. Epub 2006 Jun 25. PMID:16799561[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Hernandez Prada JA, Haire RN, Allaire M, Jakoncic J, Stojanoff V, Cannon JP, Litman GW, Ostrov DA. Ancient evolutionary origin of diversified variable regions demonstrated by crystal structures of an immune-type receptor in amphioxus. Nat Immunol. 2006 Aug;7(8):875-82. Epub 2006 Jun 25. PMID:16799561 doi:10.1038/ni1359
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