1s4j
From Proteopedia
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[[Image:1s4j.gif|left|200px]] | [[Image:1s4j.gif|left|200px]] | ||
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'''NMR structure of cross-reactive peptides from Homo sapiens''' | '''NMR structure of cross-reactive peptides from Homo sapiens''' | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1S4J is a [[Single protein]] structure | + | 1S4J is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S4J OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Soares, M R.]] | [[Category: Soares, M R.]] | ||
[[Category: Valente, A P.]] | [[Category: Valente, A P.]] | ||
| - | [[Category: | + | [[Category: Antigenic peptide]] |
| - | [[Category: | + | [[Category: Chagas disease]] |
| - | [[Category: | + | [[Category: Ribosomal p2 protein]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:17:21 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 05:17, 3 May 2008
NMR structure of cross-reactive peptides from Homo sapiens
Overview
The structure of peptides corresponding to the C-terminal residues from Trypanosoma cruzi (R13), human (H13) and Leishmania braziliensis (A13) ribosomal proteins were determined using nuclear magnetic resonance. Although there is only one amino acid difference between them, the peptides present distinct structures in solution: R13 adopts a random coil conformation while H13 and A13 form a bend. Interaction of these peptides with polyclonal antibodies from chronic Chagas' disease patients and a monoclonal antibody raised against T. cruzi ribosomal P2beta protein was probed by transferred NOE. The results show that the flexibility of R13 is fundamental for the binding to the antibody.
About this Structure
1S4J is a Single protein structure. Full crystallographic information is available from OCA.
Reference
Correlation between conformation and antibody binding: NMR structure of cross-reactive peptides from T. cruzi, human and L. braziliensis., Soares MR, Bisch PM, Campos de Carvalho AC, Valente AP, Almeida FC, FEBS Lett. 2004 Feb 27;560(1-3):134-40. PMID:14988012 Page seeded by OCA on Sat May 3 08:17:21 2008
