1zvm
From Proteopedia
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<StructureSection load='1zvm' size='340' side='right'caption='[[1zvm]], [[Resolution|resolution]] 2.20Å' scene=''> | <StructureSection load='1zvm' size='340' side='right'caption='[[1zvm]], [[Resolution|resolution]] 2.20Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[1zvm]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[1zvm]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZVM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZVM FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
| - | + | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zvm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zvm OCA], [https://pdbe.org/1zvm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zvm RCSB], [https://www.ebi.ac.uk/pdbsum/1zvm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zvm ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zvm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zvm OCA], [https://pdbe.org/1zvm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zvm RCSB], [https://www.ebi.ac.uk/pdbsum/1zvm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zvm ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/CD38_HUMAN CD38_HUMAN] Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system. | |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Almo | + | [[Category: Almo SC]] |
| - | [[Category: Sauve | + | [[Category: Sauve A]] |
| - | [[Category: Schramm | + | [[Category: Schramm VL]] |
| - | [[Category: Shi | + | [[Category: Shi W]] |
| - | [[Category: Yang | + | [[Category: Yang T]] |
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Revision as of 08:13, 15 May 2024
Crystal structure of human CD38: cyclic-ADP-ribosyl synthetase/NAD+ glycohydrolase
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Categories: Homo sapiens | Large Structures | Almo SC | Sauve A | Schramm VL | Shi W | Yang T
