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1s58
From Proteopedia
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[[Image:1s58.jpg|left|200px]] | [[Image:1s58.jpg|left|200px]] | ||
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'''The structure of B19 parvovirus capsid''' | '''The structure of B19 parvovirus capsid''' | ||
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==About this Structure== | ==About this Structure== | ||
| - | + | Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S58 OCA]. | |
==Reference== | ==Reference== | ||
The structure of human parvovirus B19., Kaufmann B, Simpson AA, Rossmann MG, Proc Natl Acad Sci U S A. 2004 Aug 10;101(32):11628-33. Epub 2004 Aug 2. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15289612 15289612] | The structure of human parvovirus B19., Kaufmann B, Simpson AA, Rossmann MG, Proc Natl Acad Sci U S A. 2004 Aug 10;101(32):11628-33. Epub 2004 Aug 2. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15289612 15289612] | ||
| - | [[Category: Human parvovirus b19]] | ||
| - | [[Category: Protein complex]] | ||
[[Category: Kaufmann, B.]] | [[Category: Kaufmann, B.]] | ||
[[Category: Rossmann, M G.]] | [[Category: Rossmann, M G.]] | ||
[[Category: Simpson, A A.]] | [[Category: Simpson, A A.]] | ||
| - | [[Category: | + | [[Category: Beta-barrel]] |
| - | [[Category: | + | [[Category: Icosahedral capsid]] |
| - | [[Category: | + | [[Category: Icosahedral virus]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:18:52 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 05:18, 3 May 2008
The structure of B19 parvovirus capsid
Overview
Human parvovirus B19 is the only parvovirus known to be a human pathogen. The structure of recombinant B19-like particles has been determined to approximately 3.5-A resolution by x-ray crystallography and, to our knowledge, represents the first near-atomic structure of an Erythrovirus. The polypeptide fold of the major capsid protein VP2 is a "jelly roll" with a beta-barrel motif similar to that found in many icosahedral viruses. The large loops connecting the strands of the beta-barrel form surface features that differentiate B19 from other parvoviruses. Although B19 VP2 has only 26% sequence identity to VP3 of adeno-associated virus, 72% of the C(alpha) atoms can be aligned structurally with a rms deviation of 1.8 A. Both viruses require an integrin as a coreceptor, and conserved surface features suggest a common receptor-binding region.
About this Structure
Full crystallographic information is available from OCA.
Reference
The structure of human parvovirus B19., Kaufmann B, Simpson AA, Rossmann MG, Proc Natl Acad Sci U S A. 2004 Aug 10;101(32):11628-33. Epub 2004 Aug 2. PMID:15289612 Page seeded by OCA on Sat May 3 08:18:52 2008
