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1zwi

From Proteopedia

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Current revision (08:13, 15 May 2024) (edit) (undo)
 
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<StructureSection load='1zwi' size='340' side='right'caption='[[1zwi]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
<StructureSection load='1zwi' size='340' side='right'caption='[[1zwi]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1zwi]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/"actinomyces_lividans"_krasil'nikov_et_al._1965 "actinomyces lividans" krasil'nikov et al. 1965] and [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZWI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZWI FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1zwi]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Streptomyces_lividans Streptomyces lividans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZWI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZWI FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DGA:DIACYL+GLYCEROL'>DGA</scene>, <scene name='pdbligand=F09:NONAN-1-OL'>F09</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">kcsA, skc1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1916 "Actinomyces lividans" Krasil'nikov et al. 1965])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DGA:DIACYL+GLYCEROL'>DGA</scene>, <scene name='pdbligand=F09:NONAN-1-OL'>F09</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zwi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zwi OCA], [https://pdbe.org/1zwi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zwi RCSB], [https://www.ebi.ac.uk/pdbsum/1zwi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zwi ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zwi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zwi OCA], [https://pdbe.org/1zwi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zwi RCSB], [https://www.ebi.ac.uk/pdbsum/1zwi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zwi ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/KCSA_STRLI KCSA_STRLI]] Acts as a pH-gated potassium ion channel; changing the cytosolic pH from 7 to 4 opens the channel, although it is not clear if this is the physiological stimulus for channel opening. Monovalent cation preference is K(+) > Rb(+) > NH4(+) >> Na(+) > Li(+).<ref>PMID:7489706</ref>
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[https://www.uniprot.org/uniprot/KCSA_STRLI KCSA_STRLI] Acts as a pH-gated potassium ion channel; changing the cytosolic pH from 7 to 4 opens the channel, although it is not clear if this is the physiological stimulus for channel opening. Monovalent cation preference is K(+) > Rb(+) > NH4(+) >> Na(+) > Li(+).<ref>PMID:7489706</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Actinomyces lividans krasil'nikov et al. 1965]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Lk3 transgenic mice]]
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[[Category: Mus musculus]]
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[[Category: Cordero-Morales, J F]]
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[[Category: Streptomyces lividans]]
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[[Category: Cortes, D M]]
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[[Category: Cordero-Morales JF]]
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[[Category: Cuello, L G]]
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[[Category: Cortes DM]]
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[[Category: Jogini, V]]
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[[Category: Cuello LG]]
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[[Category: Perozo, E]]
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[[Category: Jogini V]]
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[[Category: Roux, B]]
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[[Category: Perozo E]]
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[[Category: Zhao, Y]]
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[[Category: Roux B]]
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[[Category: Immune system-ion transport complex]]
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[[Category: Zhao Y]]
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[[Category: Potassium ion channel]]
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[[Category: Transmembrane protein]]
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[[Category: X-ray crystallography]]
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Current revision

Structure of mutant KcsA potassium channel

PDB ID 1zwi

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