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1zy3

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Current revision (08:14, 15 May 2024) (edit) (undo)
 
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==Structural model of complex of Bcl-w protein with Bid BH3-peptide==
==Structural model of complex of Bcl-w protein with Bid BH3-peptide==
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<StructureSection load='1zy3' size='340' side='right'caption='[[1zy3]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
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<StructureSection load='1zy3' size='340' side='right'caption='[[1zy3]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1zy3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZY3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZY3 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1zy3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZY3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZY3 FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1mk3|1mk3]]</div></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zy3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zy3 OCA], [https://pdbe.org/1zy3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zy3 RCSB], [https://www.ebi.ac.uk/pdbsum/1zy3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zy3 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zy3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zy3 OCA], [https://pdbe.org/1zy3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zy3 RCSB], [https://www.ebi.ac.uk/pdbsum/1zy3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zy3 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/B2CL2_HUMAN B2CL2_HUMAN]] Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX.<ref>PMID:8761287</ref> [[https://www.uniprot.org/uniprot/BID_HUMAN BID_HUMAN]] The major proteolytic product p15 BID allows the release of cytochrome c (By similarity). Isoform 1, isoform 2 and isoform 4 induce ICE-like proteases and apoptosis. Isoform 3 does not induce apoptosis. Counters the protective effect of Bcl-2.<ref>PMID:14583606</ref>
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[https://www.uniprot.org/uniprot/B2CL2_HUMAN B2CL2_HUMAN] Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX.<ref>PMID:8761287</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Denisov, A Y]]
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[[Category: Denisov AY]]
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[[Category: Gehring, K]]
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[[Category: Gehring K]]
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[[Category: Apoptosis]]
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[[Category: Bcl-w]]
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[[Category: Bh3-peptide]]
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Current revision

Structural model of complex of Bcl-w protein with Bid BH3-peptide

PDB ID 1zy3

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