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2a3u

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Current revision (08:15, 15 May 2024) (edit) (undo)
 
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<StructureSection load='2a3u' size='340' side='right'caption='[[2a3u]], [[Resolution|resolution]] 1.34&Aring;' scene=''>
<StructureSection load='2a3u' size='340' side='right'caption='[[2a3u]], [[Resolution|resolution]] 1.34&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2a3u]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_pneumoniae"_(schroeter_1886)_flugge_1886 "bacillus pneumoniae" (schroeter 1886) flugge 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A3U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2A3U FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2a3u]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Klebsiella_pneumoniae Klebsiella pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A3U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2A3U FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=MA4:CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE'>MA4</scene>, <scene name='pdbligand=TSL:TRANS-ENAMINE+INTERMEDIATE+OF+SULBACTAM'>TSL</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.34&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1rcj|1rcj]], [[2a49|2a49]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=MA4:CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE'>MA4</scene>, <scene name='pdbligand=TSL:TRANS-ENAMINE+INTERMEDIATE+OF+SULBACTAM'>TSL</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">bla, shv1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=573 "Bacillus pneumoniae" (Schroeter 1886) Flugge 1886])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2a3u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a3u OCA], [https://pdbe.org/2a3u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2a3u RCSB], [https://www.ebi.ac.uk/pdbsum/2a3u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2a3u ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2a3u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a3u OCA], [https://pdbe.org/2a3u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2a3u RCSB], [https://www.ebi.ac.uk/pdbsum/2a3u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2a3u ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/BLA1_KLEPN BLA1_KLEPN]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Beta-lactamase]]
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[[Category: Klebsiella pneumoniae]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Akker, F van den]]
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[[Category: Bonomo RA]]
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[[Category: Bonomo, R A]]
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[[Category: Carey MP]]
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[[Category: Carey, M P]]
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[[Category: Carey PR]]
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[[Category: Carey, P R]]
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[[Category: Helfand MS]]
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[[Category: Helfand, M S]]
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[[Category: Padayatti PS]]
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[[Category: Padayatti, P S]]
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[[Category: Totir MA]]
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[[Category: Totir, M A]]
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[[Category: Van den Akker F]]
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[[Category: Beta-lactam hydrolase]]
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[[Category: Covalent intermediate]]
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[[Category: Detergent binding]]
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[[Category: Hydrolase]]
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[[Category: Inhibitor design]]
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[[Category: Penicillinase]]
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Current revision

Crystal structure of sulbactam bound to E166A variant of SHV-1 beta-lactamase

PDB ID 2a3u

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