2a55

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==Solution structure of the two N-terminal CCP modules of C4b-binding protein (C4BP) alpha-chain.==
==Solution structure of the two N-terminal CCP modules of C4b-binding protein (C4BP) alpha-chain.==
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<StructureSection load='2a55' size='340' side='right'caption='[[2a55]], [[NMR_Ensembles_of_Models | 40 NMR models]]' scene=''>
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<StructureSection load='2a55' size='340' side='right'caption='[[2a55]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2a55]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A55 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2A55 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2a55]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A55 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2A55 FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">C4BPA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2a55 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a55 OCA], [https://pdbe.org/2a55 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2a55 RCSB], [https://www.ebi.ac.uk/pdbsum/2a55 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2a55 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2a55 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a55 OCA], [https://pdbe.org/2a55 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2a55 RCSB], [https://www.ebi.ac.uk/pdbsum/2a55 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2a55 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/C4BPA_HUMAN C4BPA_HUMAN]] Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with anticoagulant protein S and with serum amyloid P component.
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[https://www.uniprot.org/uniprot/C4BPA_HUMAN C4BPA_HUMAN] Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with anticoagulant protein S and with serum amyloid P component.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Ball, G]]
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[[Category: Ball G]]
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[[Category: Barlow, P N]]
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[[Category: Barlow PN]]
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[[Category: Blom, A M]]
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[[Category: Blom AM]]
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[[Category: Jenkins, H T]]
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[[Category: Jenkins HT]]
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[[Category: Lindahl, G]]
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[[Category: Lindahl G]]
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[[Category: Mark, L]]
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[[Category: Mark L]]
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[[Category: Uhrin, D]]
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[[Category: Uhrin D]]
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[[Category: Ccp module]]
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[[Category: Complement]]
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[[Category: Immune system]]
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[[Category: Scr]]
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Revision as of 08:15, 15 May 2024

Solution structure of the two N-terminal CCP modules of C4b-binding protein (C4BP) alpha-chain.

PDB ID 2a55

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