Epidermal growth factor receptor substrate
From Proteopedia
(Difference between revisions)
| Line 17: | Line 17: | ||
== Structural highlights == | == Structural highlights == | ||
| - | The 3D structure of the complex between Eps8 SH3 domain and the kinase NleH peptide shows <scene name='10/1046375/Cv/3'>the interaction of the PxxDY motif with Eps8 via multiple hydrogen bonds</scene><ref>PMID:35976880</ref>. The water molecules are shown as red spheres. The C-terminal SAM domain of Eps8 contains the actin binding motif LNK and the phosphorylated Ser residue. | + | The 3D structure of the complex between Eps8 SH3 domain and the kinase NleH peptide shows <scene name='10/1046375/Cv/3'>the interaction of the PxxDY motif with Eps8 via multiple hydrogen bonds</scene><ref>PMID:35976880</ref> (PDB code [[7tzk]]). The water molecules are shown as red spheres. The C-terminal SAM domain of Eps8 contains the actin binding motif LNK and the phosphorylated Ser residue. |
== Epidermal growth factor receptor substrate 3D structures== | == Epidermal growth factor receptor substrate 3D structures== | ||
Revision as of 06:22, 16 May 2024
| |||||||||||
References
- ↑ Fazioli F, Minichiello L, Matoska V, Castagnino P, Miki T, Wong WT, Di Fiore PP. Eps8, a substrate for the epidermal growth factor receptor kinase, enhances EGF-dependent mitogenic signals. EMBO J. 1993 Oct;12(10):3799-808. PMID:8404850
- ↑ Xu M, Shorts-Cary L, Knox AJ, Kleinsmidt-DeMasters B, Lillehei K, Wierman ME. Epidermal growth factor receptor pathway substrate 8 is overexpressed in human pituitary tumors: role in proliferation and survival. Endocrinology. 2009 May;150(5):2064-71. PMID:19116338 doi:10.1210/en.2008-1265
- ↑ Salcini AE, Chen H, Iannolo G, De Camilli P, Di Fiore PP. Epidermal growth factor pathway substrate 15, Eps15. Int J Biochem Cell Biol. 1999 Aug;31(8):805-9. PMID:10481267 doi:10.1016/s1357-2725(99)00042-4
- ↑ Li Q, Bao W, Fan Q, Shi WJ, Li ZN, Xu Y, Wu D. Epidermal growth factor receptor kinase substrate 8 promotes the metastasis of cervical cancer via the epithelial-mesenchymal transition. Mol Med Rep. 2016 Oct;14(4):3220-8. PMID:27573546 doi:10.3892/mmr.2016.5638
- ↑ Pollock GL, Grishin AM, Giogha C, Gan J, Oates CV, McMillan PJ, Gaeta I, Tyska MJ, Pearson JS, Scott NE, Cygler M, Hartland EL. Targeting of microvillus protein Eps8 by the NleH effector kinases from enteropathogenic E. coli. Proc Natl Acad Sci U S A. 2022 Aug 23;119(34):e2204332119. doi:, 10.1073/pnas.2204332119. Epub 2022 Aug 17. PMID:35976880 doi:http://dx.doi.org/10.1073/pnas.2204332119
