Engulfment and cell motility protein 1
From Proteopedia
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== Function == | == Function == | ||
| - | '''Engulfment and cell motility protein 1''' (ELMO1) or '''CED-12 homolog''' mediates tumour progression by increasing cell motility and inhibiting apoptosis in human colorectal cancer<ref>PMID:36288887</ref>. | + | '''Engulfment and cell motility protein 1''' (ELMO1) or '''CED-12 homolog''' mediates tumour progression by increasing cell motility and inhibiting apoptosis in human colorectal cancer<ref>PMID:36288887</ref>. Complex formation of ELMO1 with dedicator of cytokinesis 2 (DOCK2) is necessary for DOCK2-mediated Rac signaling. |
== Disease == | == Disease == | ||
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== Structural highlights == | == Structural highlights == | ||
| - | + | The complex of ELMO1 and DOCK2 is formed between the C-terminal of ELMO1 and the SH3 domain of DOCK2. The Pro-rich C-terminal of ELMO1 forms a five helix bundle with the DOCK2 SH3 domain. | |
== 3D structures of engulfment and cell motility protein 1 == | == 3D structures of engulfment and cell motility protein 1 == | ||
Revision as of 09:01, 16 May 2024
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References
- ↑ Park YL, Cho SB, Park SY, Oh HH, Myung E, Im CM, Son S, Kim S, Cho SY, Chung MW, Hong JY, Kim KH, Myung DS, Lee WS, Park D, Joo YE. Engulfment and Cell Motility 1 (ELMO1) Regulates Tumor Cell Behavior and Predicts Prognosis in Colorectal Cancer. Anticancer Res. 2022 Nov;42(11):5343-5355. PMID:36288887 doi:10.21873/anticanres.16058
- ↑ Kakoki M, Bahnson EM, Hagaman JR, Siletzky RM, Grant R, Kayashima Y, Li F, Lee EY, Sun MT, Taylor JM, Rice JC, Almeida MF, Bahr BA, Jennette JC, Smithies O, Maeda-Smithies N. Engulfment and cell motility protein 1 potentiates diabetic cardiomyopathy via Rac-dependent and Rac-independent ROS production. JCI Insight. 2019 Jun 20;4(12):e127660. PMID:31217360 doi:10.1172/jci.insight.127660
