1s5z

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[[Image:1s5z.gif|left|200px]]
[[Image:1s5z.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1s5z |SIZE=350|CAPTION= <scene name='initialview01'>1s5z</scene>, resolution 2.&Aring;
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The line below this paragraph, containing "STRUCTURE_1s5z", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SON:ADENOSINE+PHOSPHONOACETIC+ACID'>SON</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Nucleoside-diphosphate_kinase Nucleoside-diphosphate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.6 2.7.4.6] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= NDKC, NDKB, GIP17, DD_02290, DD_02289 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=44689 Dictyostelium discoideum])
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-->
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|DOMAIN=
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{{STRUCTURE_1s5z| PDB=1s5z | SCENE= }}
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|RELATEDENTRY=[[1ndc|1NDC]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1s5z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s5z OCA], [http://www.ebi.ac.uk/pdbsum/1s5z PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1s5z RCSB]</span>
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}}
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'''NDP kinase in complex with adenosine phosphonoacetic acid'''
'''NDP kinase in complex with adenosine phosphonoacetic acid'''
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[[Category: Solaroli, N.]]
[[Category: Solaroli, N.]]
[[Category: Veron, M.]]
[[Category: Veron, M.]]
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[[Category: transferase]]
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[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:20:41 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:37:52 2008''
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Revision as of 05:20, 3 May 2008

Image:1s5z.gif

Template:STRUCTURE 1s5z

NDP kinase in complex with adenosine phosphonoacetic acid


Overview

NDP kinase catalyzes the last step in the phosphorylation of nucleotides. It is also involved in the activation by cellular kinases of nucleoside analogs used in antiviral therapies. Adenosine phosphonoacetic acid, a close analog of ADP already proposed as an inhibitor of ribonucleotide reductase, was found to be a poor substrate for human NDP kinase, as well as a weak inhibitor with an equilibrium dissociation constant of 0.6 mM to be compared to 0.025 mM for ADP. The X-ray structure of a complex of adenosine phosphonoacetic acid and the NDP kinase from Dictyostelium was determined to 2.0 A resolution showing that the analog adopts a binding mode similar to ADP, but that no magnesium ion is present at the active site. As ACP may also interfere with other cellular kinases, its potential as a drug targeting NDP kinase or ribonucleotide reductase is likely to be limited due to strong side effects. The design of new molecules with a narrower specificity and a stronger affinity will benefit from the detailed knowledge of the complex ACP-NDP kinase.

About this Structure

1S5Z is a Single protein structure of sequence from Dictyostelium discoideum. Full crystallographic information is available from OCA.

Reference

Adenosine phosphonoacetic acid is slowly metabolized by NDP kinase., Chen Y, Morera S, Pasti C, Angusti A, Solaroli N, Veron M, Janin J, Manfredini S, Deville-Bonne D, Med Chem. 2005 Nov;1(6):529-36. PMID:16787337 Page seeded by OCA on Sat May 3 08:20:41 2008

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